MULTISPECIES: nucleoside permease [Enterobacteriaceae].

LOCUS       WP_000858484             425 aa            linear   BCT 28-MAR-2023
ACCESSION   WP_000858484
VERSION     WP_000858484.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 425)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 425)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   3  (residues 1 to 425)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
REFERENCE   4  (residues 1 to 425)
  AUTHORS   Law,C.J., Maloney,P.C. and Wang,D.N.
  TITLE     Ins and outs of major facilitator superfamily antiporters
  JOURNAL   Annu Rev Microbiol 62, 289-305 (2008)
   PUBMED   18537473
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10017491
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..425
                     /product="nucleoside permease"
                     /GO_function="GO:0015506 - nucleoside:proton symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015858 - nucleoside transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47228
     Region          1..419
                     /region_name="2A0110"
                     /note="nucleoside transporter; TIGR00889"
                     /db_xref="CDD:129967"
     Site            order(14..15,18..19,22,54,105..106,108..110,113,131,
                     134..135,138,218,221..222,225..227,230,255,259,313..314,
                     318,322,338,341..342,345..346,349)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340866"
ORIGIN      
        1 mkttaklsfm mfvewfiwga wfvplwlwls ksgfsageig wsyactaiaa ilspilvgsi
       61 tdrffsaqkv lavlmfagal lmyfaaqqtt fagffpllla ysltymptia ltnsiafanv
      121 pdverdfpri rvmgtigwia sglacgflpq ilgyadispt nipllitags sallgvfaff
      181 lpdtppkstg kmdikvmlgl dalillrdkn flvfffcsfl famplafyyi fangyltevg
      241 mknatgwmtl gqfseiffml alpfftkrfg ikkvlllglv taairygffi ygsadeyfty
      301 allflgillh gvsydfyyvt ayiyvdkkap vhmrtaaqgl itlccqgfgs llgyrlggvm
      361 mekmfayqep vngltfnwsg mwtfgavmia iiavlfmiff resdneitai kvddrdialt
      421 qgevk