MULTISPECIES: L-threonate dehydrogenase [Escherichia].

LOCUS       WP_000848004             302 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_000848004
VERSION     WP_000848004.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 302)
  AUTHORS   Zhang,X., Carter,M.S., Vetting,M.W., San Francisco,B., Zhao,S.,
            Al-Obaidi,N.F., Solbiati,J.O., Thiaville,J.J., de Crecy-Lagard,V.,
            Jacobson,M.P., Almo,S.C. and Gerlt,J.A.
  TITLE     Assignment of function to a domain of unknown function: DUF1537 is
            a new kinase family in catabolic pathways for acid sugars
  JOURNAL   Proc Natl Acad Sci U S A 113 (29), E4161-E4169 (2016)
   PUBMED   27402745
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF043037.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     gene            1..302
                     /gene="ltnD"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
     Protein         1..302
                     /product="L-threonate dehydrogenase"
                     /EC_number="1.1.1.411"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=30620
     Region          8..292
                     /region_name="MmsB"
                     /note="3-hydroxyisobutyrate dehydrogenase or related
                     beta-hydroxyacid dehydrogenase [Lipid transport and
                     metabolism]; COG2084"
                     /db_xref="CDD:441687"
ORIGIN      
        1 mktgsefhvg ivglgsmgmg aalsyvragl stwgadlnsn acatlkeaga cgvsdnaatf
       61 aekldallvl vvnaaqvkqv lfgetgvaqh lkpgtavmvs stiasadaqe iatalagfdl
      121 emldapvsgg avkaangemt vmasgsdiaf erlapvleav agkvyrigae pglgstvkii
      181 hqllagvhia agaeamalaa ragipldvmy dvvtnaagns wmfenrmrhv vdgdytphsa
      241 vdifvkdlgl vadtakalhf plplastaln mftsasnagy gkeddsavik ifsgitlpga
      301 ks