MULTISPECIES: H(+)/Cl(-) exchange transporter ClcA [Salmonella].

LOCUS       WP_000845427             473 aa            linear   BCT 17-OCT-2022
ACCESSION   WP_000845427
VERSION     WP_000845427.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003640.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05277
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..473
                     /gene="clcA"
     Protein         1..473
                     /product="H(+)/Cl(-) exchange transporter ClcA"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50350
     Region          36..473
                     /region_name="PRK05277"
                     /note="H(+)/Cl(-) exchange transporter ClcA"
                     /db_xref="CDD:235385"
     Site            order(106..110,146..150,355..359,445)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238504"
     Site            order(107,109,148..149,355..357,445)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238504"
     Site            148
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238504"
     Site            order(194,203,216,223,403,406,414,426,433..434,437)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238504"
     Site            203
                     /site_type="active"
                     /note="H+/Cl- coupling transport residue [active]"
                     /db_xref="CDD:238504"
ORIGIN      
        1 mktdtstfla qqivrlrrrd qirrlmqrdk tplailfmaa vvgtltglvg vafekavswv
       61 qnmrigalvq vadhafllwp lafilsalla mvgyflvrkf apeaggsgip eiegaleelr
      121 pvrwwrvlpv kfiggmgtlg agmvlgregp tvqiggnlgr mvldvfrmrs aearhtllat
      181 gaaaglsaaf naplagilfi ieemrpqfry nlisikavft gvimssivfr ifngeapiie
      241 vgklsdapvn tlwlylilgi ifgcvgpvfn slvlrtqdmf qrfhggeikk wvlmggaigg
      301 lcgilgliep aaagggfnli piaaagnfsv glllfifitr vvttllcfss gapggifapm
      361 lalgtllgta fgmaaavlfp qyhleagtfa iagmgalmaa svrapltgiv lvlemtdnyq
      421 lilpmiitcl gatllaqflg gkplystila rtlakqdaeq aeknqnapad ent