MULTISPECIES: H(+)/Cl(-) exchange transporter ClcA

LOCUS       WP_000845408             473 aa            linear   BCT 17-OCT-2022
            [Enterobacteriaceae].
ACCESSION   WP_000845408
VERSION     WP_000845408.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003640.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05277
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..473
                     /gene="clcA"
     Protein         1..473
                     /product="H(+)/Cl(-) exchange transporter ClcA"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50204
     Region          36..473
                     /region_name="PRK05277"
                     /note="H(+)/Cl(-) exchange transporter ClcA"
                     /db_xref="CDD:235385"
     Site            order(106..110,146..150,355..359,445)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238504"
     Site            order(107,109,148..149,355..357,445)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238504"
     Site            148
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238504"
     Site            order(194,203,216,223,403,406,414,426,433..434,437)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238504"
     Site            203
                     /site_type="active"
                     /note="H+/Cl- coupling transport residue [active]"
                     /db_xref="CDD:238504"
ORIGIN      
        1 mktdtpslet pqaarlrrrq lirqllerdk tplailfmaa vvgtlvglaa vafdkgvawl
       61 qnqrmgalvh tadnyplllt vaflcsavla mfgyflvrky apeaggsgip eiegaledqr
      121 pvrwwrvlpv kffgglgtlg ggmvlgregp tvqiggnigr mvldvfrlkg dearhtllat
      181 gaaaglaaaf naplagilfi ieemrpqfry tlisikavfi gvimstimyr ifnhevalid
      241 vgklsdapln tlwlylilgi ifgifgpifn kwvlgmqdll hrvhggnitk wvlmggaigg
      301 lcgllgfvap atsgggfnli piatagnfsm gmlvfifvar vittllcfss gapggifapm
      361 lalgtvlgta fgmvavelfp qyhleagtfa iagmgallaa sirapltgii lvlemtdnyq
      421 lilpmiitgl gatllaqftg gkplysaila rtlakqeaeq larskaasas ent