MULTISPECIES: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

LOCUS       WP_000811924             398 aa            linear   BCT 17-SEP-2024
            [Enterobacteriaceae].
ACCESSION   WP_000811924
VERSION     WP_000811924.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 398)
  AUTHORS   Haymond,A., Johny,C., Dowdy,T., Schweibenz,B., Villarroel,K.,
            Young,R., Mantooth,C.J., Patel,T., Bases,J., San Jose,G.,
            Jackson,E.R., Dowd,C.S. and Couch,R.D.
  TITLE     Kinetic characterization and allosteric inhibition of the Yersinia
            pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP
            synthase)
  JOURNAL   PLoS One 9 (8), e106243 (2014)
   PUBMED   25171339
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003938.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05447
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..398
                     /gene="ispC"
     Protein         1..398
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /EC_number="1.1.1.267"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43230
     Region          1..398
                     /region_name="PRK05447"
                     /note="1-deoxy-D-xylulose 5-phosphate reductoisomerase;
                     Provisional"
                     /db_xref="CDD:235472"
ORIGIN      
        1 mkqltilgst gsigcstldv vrhnpehfrv valvagknvt rmveqclefs pryavmddea
       61 sakllktmlq qqgsrtevls gqqaacdmaa ledvdqvmaa ivgaagllpt laairagkti
      121 llankeslvt cgrlfmdavk qskaqllpvd sehnaifqsl pqpiqhnlgy adleqngvvs
      181 illtgsggpf retplrdlat mtpdqacrhp nwsmgrkisv dsatmmnkgl eyiearwlfn
      241 asasqmevli hpqsvihsmv ryqdgsvlaq lgepdmrtpi ahtmawpnrv nsgvkpldfc
      301 klsaltfaap dydrypclkl ameafeqgqa attalnaane itvaaflaqq irftdiaaln
      361 lsvlekmdmr epqcvddvls vdasarevar kevmrlas