MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

LOCUS       WP_000796483             438 aa            linear   BCT 04-JUN-2024
            [Enterobacteriaceae].
ACCESSION   WP_000796483
VERSION     WP_000796483.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 438)
  AUTHORS   Kouidmi,I., Levesque,R.C. and Paradis-Bleau,C.
  TITLE     The biology of Mur ligases as an antibacterial target
  JOURNAL   Mol Microbiol 94 (2), 242-253 (2014)
   PUBMED   25130693
REFERENCE   2  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Martin,L., Fanchon,E., Blanot,D., Le
            Beller,D., van Heijenoort,J. and Dideberg,O.
  TITLE     Determination of the MurD mechanism through crystallographic
            analysis of enzyme complexes
  JOURNAL   J Mol Biol 289 (3), 579-590 (1999)
   PUBMED   10356330
REFERENCE   3  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Fanchon,E., Martin,L., Blanot,D., van
            Heijenoort,J. and Dideberg,O.
  TITLE     Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate
            ligase from Escherichia coli
  JOURNAL   EMBO J 16 (12), 3416-3425 (1997)
   PUBMED   9218784
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01087.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..438
                     /gene="murD"
     Protein         1..438
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /EC_number="6.3.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /calculated_mol_wt=46871
     Region          3..437
                     /region_name="MurD"
                     /note="UDP-N-acetylmuramoylalanine-D-glutamate ligase
                     [Cell wall/membrane/envelope biogenesis]; COG0771"
                     /db_xref="CDD:440534"
ORIGIN      
        1 madyqgknvv iiglgltgls cvdfflargv tprvmdtrmt ppgldklpea verhtgslnd
       61 ewlmaadliv aspgialahp slsaaadagi eivgdielfc reaqapivai tgsngkstvt
      121 tlvgemakaa gvnvgvggni glpalmlldd ecelyvlels sfqlettssl qavaatilnv
      181 tedhmdrypf glqqyraakl riyenakvcv vnaddaltmp irgadercvs fgvnmgdyhl
      241 nhqqgetwlr vkgekvlnvk emklsgqhny tnalaalala daaglprass lkalttftgl
      301 phrfevvleh ngvrwindsk atnvgsteaa lnglhvdgtl hlllggdgks adfsplaryl
      361 ngdnvrlycf grdgvqlaal rpevaeqtet meqamrllap rvqpgdmvll spacasldqf
      421 knfeqrgnef arlakelg