MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

LOCUS       WP_000796445             438 aa            linear   BCT 04-JUN-2024
            [Salmonella].
ACCESSION   WP_000796445
VERSION     WP_000796445.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 438)
  AUTHORS   Kouidmi,I., Levesque,R.C. and Paradis-Bleau,C.
  TITLE     The biology of Mur ligases as an antibacterial target
  JOURNAL   Mol Microbiol 94 (2), 242-253 (2014)
   PUBMED   25130693
REFERENCE   2  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Martin,L., Fanchon,E., Blanot,D., Le
            Beller,D., van Heijenoort,J. and Dideberg,O.
  TITLE     Determination of the MurD mechanism through crystallographic
            analysis of enzyme complexes
  JOURNAL   J Mol Biol 289 (3), 579-590 (1999)
   PUBMED   10356330
REFERENCE   3  (residues 1 to 438)
  AUTHORS   Bertrand,J.A., Auger,G., Fanchon,E., Martin,L., Blanot,D., van
            Heijenoort,J. and Dideberg,O.
  TITLE     Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate
            ligase from Escherichia coli
  JOURNAL   EMBO J 16 (12), 3416-3425 (1997)
   PUBMED   9218784
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01087.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..438
                     /gene="murD"
     Protein         1..438
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /EC_number="6.3.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /calculated_mol_wt=46867
     Region          3..437
                     /region_name="MurD"
                     /note="UDP-N-acetylmuramoylalanine-D-glutamate ligase
                     [Cell wall/membrane/envelope biogenesis]; COG0771"
                     /db_xref="CDD:440534"
ORIGIN      
        1 madyqdknvv iiglgltgls cvdfflargv tprvmdtrvt ppgldklpqe verhvgglnd
       61 ewllaadliv aspgialahp slsaaasagv eivgdielfc reaqapivai tgsngkstvt
      121 tlvgemakaa gvnvgvggni glpalmllda drelyvlels sfqlettssl qaaaatvlnv
      181 tedhmdrypf glqqyraakl rvyekakvcv vnaddaltmp vrgadercvs fgvnmgdyhl
      241 nrqqgetwlr vkgekvlnvk emklsgqhny tnalaalala davglprass lkalttftgl
      301 ahrfqlaleh ngvrwindsk atnvgsteaa lnglhvdgtl hlllggdgks adfspltryl
      361 tgdrirlycf grdgaqlaal rpeiaqqtet meeamrllap rvqpgdmvll spacasldqf
      421 knfeqrgdvf trlakelg