MULTISPECIES: translation elongation factor 4 [Enterobacteriaceae].

LOCUS       WP_000790168             599 aa            linear   BCT 22-MAR-2021
ACCESSION   WP_000790168
VERSION     WP_000790168.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Gibbs,M.R., Moon,K.M., Chen,M., Balakrishnan,R., Foster,L.J. and
            Fredrick,K.
  TITLE     Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis
            of the 30S subunit of the 70S ribosome
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 980-985 (2017)
   PUBMED   28096346
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Song,G. and Qin,Y.
  TITLE     EF4 reveals the energy barrier for tRNA back-translocation in the
            peptidyl transferase center
  JOURNAL   RNA Biol 13 (10), 934-939 (2016)
   PUBMED   27472653
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Kumar,V., Ero,R., Ahmed,T., Goh,K.J., Zhan,Y., Bhushan,S. and
            Gao,Y.G.
  TITLE     Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the
            Ribosome
  JOURNAL   J Biol Chem 291 (25), 12943-12950 (2016)
   PUBMED   27137929
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Liu,H., Chen,C., Zhang,H., Kaur,J., Goldman,Y.E. and Cooperman,B.S.
  TITLE     The conserved protein EF4 (LepA) modulates the elongation cycle of
            protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 108 (39), 16223-16228 (2011)
   PUBMED   21930951
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01393.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..599
                     /gene="lepA"
     Protein         1..599
                     /product="translation elongation factor 4"
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /calculated_mol_wt=66439
     Region          1..595
                     /region_name="LepA"
                     /note="Translation elongation factor EF-4, membrane-bound
                     GTPase [Translation, ribosomal structure and biogenesis];
                     COG0481"
                     /db_xref="CDD:440249"
ORIGIN      
        1 mknirnfsii ahidhgkstl sdriiqicgg lsdremeaqv ldsmdlerer gitikaqsvt
       61 ldykasdget yqlnfidtpg hvdfsyevsr slaacegall vvdagqgvea qtlancytam
      121 emdlevvpvl nkidlpaadp ervaeeiedi vgidatdavr csaktgvgvq dvlerlvrdi
      181 pppegdpegp lqaliidswf dnylgvvsli rikngtlrkg dkvkvmstgq tynadrlgif
      241 tpkqvdrtel kcgevgwlvc aikdihgapv gdtltlarnp aekalpgfkk vkpqvyaglf
      301 pvssddyeaf rdalgklsln daslfyepes ssalgfgfrc gflgllhmei iqerlereyd
      361 ldlittaptv vyevettsre viyvdspskl pavnniyelr epiaechmll pqaylgnvit
      421 lcvekrgvqt nmvyhgnqva ltyeipmaev vldffdrlks tsrgyasldy nfkrfqasdm
      481 vrvdvlinge rvdalalith rdnsqnrgre lvekmkdlip rqqfdiaiqa aigthiiars
      541 tvkqlrknvl akcyggdisr kkkllqkqke gkkrmkqign velpqeafla ilhvgkdnk