MULTISPECIES: site-specific integrase [Escherichia].

LOCUS       WP_000741310             375 aa            linear   BCT 20-MAR-2023
ACCESSION   WP_000741310
VERSION     WP_000741310.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Grainge,I. and Jayaram,M.
  TITLE     The integrase family of recombinase: organization and function of
            the active site
  JOURNAL   Mol Microbiol 33 (3), 449-456 (1999)
   PUBMED   10577069
REFERENCE   2  (residues 1 to 375)
  AUTHORS   Gopaul,D.N. and Duyne,G.D.
  TITLE     Structure and mechanism in site-specific recombination
  JOURNAL   Curr Opin Struct Biol 9 (1), 14-20 (1999)
   PUBMED   10047575
REFERENCE   3  (residues 1 to 375)
  AUTHORS   Esposito,D. and Scocca,J.J.
  TITLE     The integrase family of tyrosine recombinases: evolution of a
            conserved active site domain
  JOURNAL   Nucleic Acids Res 25 (18), 3605-3614 (1997)
   PUBMED   9278480
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10557089
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     Protein         1..375
                     /product="site-specific integrase"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence
                     IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /calculated_mol_wt=42668
     Region          2..73
                     /region_name="Arm-DNA-bind_1"
                     /note="Bacteriophage lambda integrase, Arm DNA-binding
                     domain; pfam09003"
                     /db_xref="CDD:430365"
     Region          15..>259
                     /region_name="FimB"
                     /note="Integrase/recombinase, includes phage integrase
                     [Replication, recombination and repair, Mobilome:
                     prophages, transposons]; COG0582"
                     /db_xref="CDD:440347"
     Region          197..371
                     /region_name="INT_Lambda_C"
                     /note="C-terminal catalytic domain of Lambda integrase, a
                     tyrosine-based site-specific recombinase; cd00800"
                     /db_xref="CDD:271181"
     Site            order(197,200..201,203..204,214)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271181"
     Site            order(226,330,333,353,362)
                     /site_type="active"
                     /db_xref="CDD:271181"
ORIGIN      
        1 maarprknnv svpnlyplys rkvnkvywry khpvtgkfha lgtneaeaia iateantrla
       61 eqrtrqilai sdriatskgk aittstwldr yqaiqddrlk sgdirlntyk qkakpvsllr
      121 eragmklisa vdvrdiaqll deyiaagrpr maqvvrsvli dvfkeaqhyg evppgynpal
      181 atkqprrkit rqrlsleewk kifdiadath rymgnamlla lvtgqrlgdi srmkfsdiwd
      241 dhlhviqekt gskiaiplsl rlnainwslr dvvarcrdya vsaylvhffr stsqaergaq
      301 vkantltmnf skardlarid wgegspatfh eqrslserly keqgldtqkl lghktqqqtd
      361 ryhddrgkgw skval