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LOCUS WP_000737329 350 aa linear BCT 24-DEC-2024 ACCESSION WP_000737329 VERSION WP_000737329.1 KEYWORDS RefSeq. SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 (residues 1 to 350) AUTHORS Persson,B., Hedlund,J. and Jornvall,H. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily JOURNAL Cell Mol Life Sci 65 (24), 3879-3894 (2008) PUBMED 19011751 REFERENCE 2 (residues 1 to 350) AUTHORS Auld,D.S. and Bergman,T. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : The role of zinc for alcohol dehydrogenase structure and function JOURNAL Cell Mol Life Sci 65 (24), 3961-3970 (2008) PUBMED 19011745 REFERENCE 3 (residues 1 to 350) AUTHORS Nordling,E., Jornvall,H. and Persson,B. TITLE Medium-chain dehydrogenases/reductases (MDR). Family characterizations including genome comparisons and active site modeling JOURNAL Eur J Biochem 269 (17), 4267-4276 (2002) PUBMED 12199705 REFERENCE 4 (residues 1 to 350) AUTHORS Lesk,A.M. TITLE NAD-binding domains of dehydrogenases JOURNAL Curr Opin Struct Biol 5 (6), 775-783 (1995) PUBMED 8749365 REFERENCE 5 (residues 1 to 350) AUTHORS Persson,B., Zigler,J.S. Jr. and Jornvall,H. TITLE A super-family of medium-chain dehydrogenases/reductases (MDR). Sub-lines including zeta-crystallin, alcohol and polyol dehydrogenases, quinone oxidoreductase enoyl reductases, VAT-1 and other proteins JOURNAL Eur J Biochem 226 (1), 15-22 (1994) PUBMED 7957243 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10169599 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..350 /organism="Escherichia coli" /db_xref="taxon:562" Protein 1..350 /product="zinc-dependent alcohol dehydrogenase" /EC_number="1.1.1.-" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /GO_function="GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]" /GO_function="GO:0030554 - adenyl nucleotide binding [Evidence IEA]" /calculated_mol_wt=38100 Region 79..350 /region_name="2-desacetyl-2- hydroxyethyl_bacteriochlorophyllide_" /note="2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; cd08255" /db_xref="CDD:176217" Site order(141,145,165..170,189..190,194,212,233..234,236, 256..257,283..285) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176217" ORIGIN 1 mkklvatapr vaalveyedr ailanevkir vrfgapkhgt evvdfraasp fidedfngew 61 qmftprpada prgiefgkfq lgnmvvgdii ecgsdvtdya vgdsvcgygp lsetiiinav 121 nnyklrkmpe gsswknavcy dpaqfamsgv rdanvrvgdf vvvvglgaig qiaiqlakra 181 gasvvigvdp iahrcdiarr hgadfclnpi gtdvgkeikt ltgkqgadvi ietsgyadal 241 qsalrglayg gtisyvafak pfaegfnlgr eahfnnakiv fsracsepnp dyprwsrkri 301 eetcwkllmn gylncedlid pvvtfanspe symqyvdqhp eqsikmgvtf