alpha2-macroglobulin [Escherichia coli].

LOCUS       WP_000736260            1653 aa            linear   BCT 11-JAN-2020
ACCESSION   WP_000736260
VERSION     WP_000736260.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 1653)
  AUTHORS   Garcia-Ferrer,I., Arede,P., Gomez-Blanco,J., Luque,D.,
            Duquerroy,S., Caston,J.R., Goulas,T. and Gomis-Ruth,F.X.
  TITLE     Structural and functional insights into Escherichia coli
            alpha2-macroglobulin endopeptidase snap-trap inhibition
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 112 (27), 8290-8295 (2015)
   PUBMED   26100869
REFERENCE   2  (residues 1 to 1653)
  AUTHORS   Fyfe,C.D., Grinter,R., Josts,I., Mosbahi,K., Roszak,A.W.,
            Cogdell,R.J., Wall,D.M., Burchmore,R.J., Byron,O. and Walker,D.
  TITLE     Structure of protease-cleaved Escherichia coli
            alpha-2-macroglobulin reveals a putative mechanism of
            conformational activation for protease entrapment
  JOURNAL   Acta Crystallogr. D Biol. Crystallogr. 71 (Pt 7), 1478-1486 (2015)
   PUBMED   26143919
REFERENCE   3  (residues 1 to 1653)
  AUTHORS   Doan,N. and Gettins,P.G.
  TITLE     alpha-Macroglobulins are present in some gram-negative bacteria:
            characterization of the alpha2-macroglobulin from Escherichia coli
  JOURNAL   J. Biol. Chem. 283 (42), 28747-28756 (2008)
   PUBMED   18697741
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR007362
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..1653
                     /gene="yfhM"
     Protein         1..1653
                     /product="alpha2-macroglobulin"
                     /calculated_mol_wt=181286
     Region          32..1652
                     /region_name="YfaS"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; COG2373"
                     /db_xref="CDD:441940"
ORIGIN      
        1 mkklrvaacm lmlalagcdn ndnaptavkk dapsevtkaa ssenassakl saperqklaq
       61 qsagkaltll dlsevqldga atlvltfsip ldpdqdfsrv ihvvdkksgk vdgawelsdn
      121 lkelrlrhle pkrdlivtig kevkalnnat fskdyektit trdiqpsvgf asrgsllpgk
      181 vveglpvmal nvnnvdvnff rvkpeslpaf isqweyrnsl anwqsdkllq madlvytgrf
      241 dlnparntre klllplgdik plqqagvyla vmnqagrydy snpatlftls digvsahryh
      301 nrldiftqsl engaaqqgie vsllnekgqt ltqatsdaqg hvqlendkna alllarkdgq
      361 ttlldlklpa ldlaefniag apgyskqffm fgprdlyrpg etvilngllr dadgkalpnq
      421 pikldvikpd gqvlrsvvsq penglyhftw pldsnaatgm whirantgdn qyrmwdfhve
      481 dfmpermaln ltgektpltp ndevkfsvvg yylygapang ntlqgqlflr plreavsalp
      541 gfefgdiaae nlsrtldevq ltlddkgrge vstesqwket hsplqvifqg sllesggrpv
      601 trraeqaiwp adalpgirpq fasksvydyr tdstvkqpiv degsnaafdi vysdaqgvkk
      661 avsglqvrli rerrdyywnw sedegwqsqf dqkdlieneq tldlkadetg kvsfpvewga
      721 yrlevkapne avssvrfwag yswqdnsdgs gavrpdrvtl kldkagyrpg dtiklhiaap
      781 tagkgyamve ssegplwwqe idvpaqgldl tipvdktwnr hdlylstlvv rpgdksrsat
      841 pkravgvlhl plgdenrrld laletpakmr pnqpltvkik astkngekpk qvnvlvsavd
      901 sgvlnitdyv tpdpwqaffg qkrygadiyd iygqviegqg rlaalrfggd gdelkrggkp
      961 pvnhvnivaq qalpvtlneq gegsvtlpig dfngelrvma qawtadefgs neskvivaap
     1021 viaelnmprf masgdnsrlt lditnltdkp qklnvaltas gllelvsdsp aavelapgvr
     1081 ttlfipvral pgygdgeiqa tisglalpge tvadqhkqwk igvrpafpaq tvnygtalqp
     1141 getwaipadg lqnfspvtle gqlllsgkpp lniaryikel kaypygcleq tasglfpsly
     1201 tnaaqlqalg ikgdsdekrr asvdigisrl lqmqrdnggf alwdkngdee ywltayvmdf
     1261 lvrageqgys vptdainrgn erllrylqdp gmmsipyadn lkaskfavqs yaalvlarqq
     1321 kaplgalrei wehradaasg lpllqlgval ktmgdatrde eaialalktp rnsderiwlg
     1381 dygsplrdna lmlslleenk llpdeqysll ntlsqqafge rwlstqesna lflaartiqd
     1441 lpgkwqaqts fsaepltgek aqnsnlnsdq latlqvtnsg eqplwlrvda sgypqsaplp
     1501 annvlqierh ilgtdgksks ldslrsgdlv lvwlqvkasn svpdalvvdl lpaglelenq
     1561 nlangsasle qsggevqnll nqmqqasikh iefrddrfva avavdeyqpv tlvylaravt
     1621 pgtyqvpqpm vesmyvpqwr atgaaedlli vrp