outer membrane channel protein TolC [Escherichia coli].

LOCUS       WP_000735274             493 aa            linear   BCT 19-MAR-2020
ACCESSION   WP_000735274
VERSION     WP_000735274.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Raczkowska,A., Trzos,J., Lewandowska,O., Nieckarz,M. and
            Brzostek,K.
  TITLE     Expression of the AcrAB Components of the AcrAB-TolC Multidrug
            Efflux Pump of Yersinia enterocolitica Is Subject to Dual
            Regulation by OmpR
  JOURNAL   PLoS ONE 10 (4), e0124248 (2015)
   PUBMED   25893523
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Koronakis,V., Sharff,A., Koronakis,E., Luisi,B. and Hughes,C.
  TITLE     Crystal structure of the bacterial membrane protein TolC central to
            multidrug efflux and protein export
  JOURNAL   Nature 405 (6789), 914-919 (2000)
   PUBMED   10879525
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Koronakis,V., Li,J., Koronakis,E. and Stauffer,K.
  TITLE     Structure of TolC, the outer membrane component of the bacterial
            type I efflux system, derived from two-dimensional crystals
  JOURNAL   Mol. Microbiol. 23 (3), 617-626 (1997)
   PUBMED   9044294
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007002.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09465
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..493
                     /gene="tolC"
     Protein         1..493
                     /product="outer membrane channel protein TolC"
                     /GO_function="GO:0015562 - efflux transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=53596
     Region          1..451
                     /region_name="tolC"
                     /note="outer membrane channel protein; Reviewed; PRK09465"
                     /db_xref="CDD:236529"
ORIGIN      
        1 mkkllpilig lslsgfssls qaenlmqvyq qarlsnpelr ksaadrdaaf ekinearspl
       61 lpqlglgady tysngyrdan ginsnatsas lqltqsifdm skwraltlqe kaagiqdvty
      121 qtdqqtliln tatayfnvln aidvlsytqa qkeaiyrqld qttqrfnvgl vaitdvqnar
      181 aqydtvlane vtarnnldna veqlrqitgn yypelaalnv enfktdkpqp vnallkeaek
      241 rnlsllqarl sqdlareqir qaqdghlptl dltassgisd tsysgsktrg aagtqyddsn
      301 mgqnkvglsf slpiyqggmv nsqvkqaqyn fvgaseqles ahrsvvqtvr ssfnninasi
      361 ssinaykqav vsaqssldam eagysvgtrt ivdvldattt lynakqelan arynylinql
      421 niksalgtln eqdllalnna lskpvstnpe nvapqtpeqn aiadgyapds papvvqqtsa
      481 rtttsnghnp frn