zinc-dependent alcohol dehydrogenase family protein [Shigella

LOCUS       WP_000700775             364 aa            linear   BCT 23-DEC-2024
            flexneri].
ACCESSION   WP_000700775
VERSION     WP_000700775.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Persson,B., Hedlund,J. and Jornvall,H.
  TITLE     Medium- and short-chain dehydrogenase/reductase gene and protein
            families : the MDR superfamily
  JOURNAL   Cell Mol Life Sci 65 (24), 3879-3894 (2008)
   PUBMED   19011751
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Auld,D.S. and Bergman,T.
  TITLE     Medium- and short-chain dehydrogenase/reductase gene and protein
            families : The role of zinc for alcohol dehydrogenase structure and
            function
  JOURNAL   Cell Mol Life Sci 65 (24), 3961-3970 (2008)
   PUBMED   19011745
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Gonzalez-Duarte,R. and Albalat,R.
  TITLE     Merging protein, gene and genomic data: the evolution of the
            MDR-ADH family
  JOURNAL   Heredity (Edinb) 95 (3), 184-197 (2005)
   PUBMED   16121213
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Nordling,E., Jornvall,H. and Persson,B.
  TITLE     Medium-chain dehydrogenases/reductases (MDR). Family
            characterizations including genome comparisons and active site
            modeling
  JOURNAL   Eur J Biochem 269 (17), 4267-4276 (2002)
   PUBMED   12199705
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Lesk,A.M.
  TITLE     NAD-binding domains of dehydrogenases
  JOURNAL   Curr Opin Struct Biol 5 (6), 775-783 (1995)
   PUBMED   8749365
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Persson,B., Zigler,J.S. Jr. and Jornvall,H.
  TITLE     A super-family of medium-chain dehydrogenases/reductases (MDR).
            Sub-lines including zeta-crystallin, alcohol and polyol
            dehydrogenases, quinone oxidoreductase enoyl reductases, VAT-1 and
            other proteins
  JOURNAL   Eur J Biochem 226 (1), 15-22 (1994)
   PUBMED   7957243
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10169520
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     Protein         1..364
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /calculated_mol_wt=39170
     Region          15..362
                     /region_name="THR_DH_like"
                     /note="L-threonine dehydrogenase (TDH)-like; cd08239"
                     /db_xref="CDD:176201"
     Site            order(51..53,56,169,173,193..198,217..218,222,238,
                     261..262,264,284..285,308..310)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:176201"
     Site            order(51,53,81,169)
                     /site_type="other"
                     /note="catalytic Zn binding site [ion binding]"
                     /db_xref="CDD:176201"
ORIGIN      
        1 mkinrivneg fmktmlaayl lgnstvdlre vavptpginq vlikmkssgi cgsdvhyiyh
       61 qhcataaapd kplyqgfing hepcgqivam gqgcrhfkeg drvlvyhisg cgfcpncrrg
      121 fpisctgkgk aaygwqrdgg haeyllaeek dlillpdals yedgafiscg vgtayegilr
      181 gevsgsdnvl vvglgpvgmm ammlakgrga kriigvdmlp erlamakqlg gmdhgylatt
      241 eglpqiiael thggadvald csgnaagrll alqstadwgr vvyigetgkv efevsadlmh
      301 hqrriigswv tslfhmekca hdltdwklwp rnaithrfsl eqagdayvlm asgkcgkvvi
      361 nfpd