MULTISPECIES: Shiga toxin Stx1a subunit A [Enterobacteriaceae].

LOCUS       WP_000691354             315 aa            linear   BCT 21-APR-2024
ACCESSION   WP_000691354
VERSION     WP_000691354.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Lindsey,R.L., Prasad,A., Feldgarden,M., Gonzalez-Escalona,N.,
            Kapsak,C., Klimke,W., Melton-Celsa,A., Smith,P., Souvorov,A.,
            Truong,J. and Scheutz,F.
  TITLE     Identification and Characterization of ten Escherichia coli Strains
            Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j,
            Stx2m, and Stx2o, in the United States
  JOURNAL   Microorganisms 11 (10), 2561 (2023)
   PUBMED   37894219
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 315)
  AUTHORS   Cooling,L.L., Walker,K.E., Gille,T. and Koerner,T.A.
  TITLE     Shiga toxin binds human platelets via globotriaosylceramide (Pk
            antigen) and a novel platelet glycosphingolipid
  JOURNAL   Infect Immun 66 (9), 4355-4366 (1998)
   PUBMED   9712788
REFERENCE   3  (residues 1 to 315)
  AUTHORS   Endo,Y., Tsurugi,K., Yutsudo,T., Takeda,Y., Ogasawara,T. and
            Igarashi,K.
  TITLE     Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7
            and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase
            activity of the toxins
  JOURNAL   Eur J Biochem 171 (1-2), 45-50 (1988)
   PUBMED   3276522
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category :: Antimicrobial Resistance Protein
            Evidence Source   :: Bacterial Antimicrobial Resistance Reference
                                 Gene Database
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..315
                     /gene="stxA1a"
     Protein         1..315
                     /product="Shiga toxin Stx1a subunit A"
                     /calculated_mol_wt=34683
     Region          30..232
                     /region_name="RIP"
                     /note="Ribosome inactivating protein; pfam00161"
                     /db_xref="CDD:459695"
ORIGIN      
        1 mkiiifrvlt fffvifsvnv vakeftldfs taktyvdsln virsaigtpl qtissggtsl
       61 lmidsgtgdn lfavdvrgid peegrfnnlr livernnlyv tgfvnrtnnv fyrfadfshv
      121 tfpgttavtl sgdssyttlq rvagisrtgm qinrhsltts yldlmshsgt sltqsvaram
      181 lrfvtvtaea lrfrqiqrgf rttlddlsgr syvmtaedvd ltlnwgrlss vlpdyhgqds
      241 vrvgrisfgs inailgsval ilnchhhasr varmasdefp smcpadgrvr githnkilwd
      301 sstlgailmr rtiss