D-mannonate dehydratase ManD [Shigella flexneri].

LOCUS       WP_000690944             404 aa            linear   BCT 22-OCT-2023
ACCESSION   WP_000690944
VERSION     WP_000690944.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Wichelecki,D.J., Balthazor,B.M., Chau,A.C., Vetting,M.W.,
            Fedorov,A.A., Fedorov,E.V., Lukk,T., Patskovsky,Y.V., Stead,M.B.,
            Hillerich,B.S., Seidel,R.D., Almo,S.C. and Gerlt,J.A.
  TITLE     Discovery of function in the enolase superfamily: D-mannonate and
            d-gluconate dehydratases in the D-mannonate dehydratase subgroup
  JOURNAL   Biochemistry 53 (16), 2722-2731 (2014)
   PUBMED   24697546
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Rakus,J.F., Fedorov,A.A., Fedorov,E.V., Glasner,M.E., Vick,J.E.,
            Babbitt,P.C., Almo,S.C. and Gerlt,J.A.
  TITLE     Evolution of enzymatic activities in the enolase superfamily:
            D-Mannonate dehydratase from Novosphingobium aromaticivorans
  JOURNAL   Biochemistry 46 (45), 12896-12908 (2007)
   PUBMED   17944491
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF043051.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     gene            1..404
                     /gene="manD"
     Protein         1..404
                     /product="D-mannonate dehydratase ManD"
                     /EC_number="4.2.1.8"
                     /GO_function="GO:0008927 - mannonate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016052 - carbohydrate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=45658
     Region          1..404
                     /region_name="PRK15072"
                     /note="D-galactonate dehydratase family protein"
                     /db_xref="CDD:237901"
     Site            order(120,147,149,212,236,238,264,287,314,341)
                     /site_type="active"
                     /note="putative active site pocket [active]"
                     /db_xref="CDD:239438"
     Site            order(212,238,264)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:239438"
ORIGIN      
        1 mkiiaadvfv tcpgrnfvtl kittesglcg lgdatlngre lsvasylkdy lcpqligrda
       61 sriediwqff ykgaywrrgp vtmsaisaid malwdikaka anmplyqllg gasregvmvy
      121 chttgrtide vledyakhqq mgfkairvqc gvpgmqttyg lakgkglaye patkglwpee
      181 qlwssekyld ftpklfeavr nkfgfnehll hdmhhrltpi eaarfgksie dyrlfwmedp
      241 tpaenqecfr lirqhtvtpi avgevfnsiw dckqlieeql igyirttith aggitgmrri
      301 adfaslyqvr tgshgpsdls pvchaaalhf dlwvpnfgvq eymgyseqml evfpyswrfe
      361 egymhpgdep glgisfdekl aakypydpey lpvarledgt llnw