MULTISPECIES: alpha-2-macroglobulin family protein [Salmonella].

LOCUS       WP_000681858            1644 aa            linear   BCT 24-DEC-2024
ACCESSION   WP_000681858
VERSION     WP_000681858.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 1644)
  AUTHORS   Arimura,Y. and Funabiki,H.
  TITLE     Structural Mechanics of the Alpha-2-Macroglobulin Transformation
  JOURNAL   J Mol Biol 434 (5), 167413 (2022)
   PUBMED   34942166
REFERENCE   2  (residues 1 to 1644)
  AUTHORS   Wong,S.G. and Dessen,A.
  TITLE     Structure of a bacterial alpha2-macroglobulin reveals mimicry of
            eukaryotic innate immunity
  JOURNAL   Nat Commun 5, 4917 (2014)
   PUBMED   25221932
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1644)
  AUTHORS   Halaby,D.M., Poupon,A. and Mornon,J.
  TITLE     The immunoglobulin fold family: sequence analysis and 3D structure
            comparisons
  JOURNAL   Protein Eng 12 (7), 563-571 (1999)
   PUBMED   10436082
REFERENCE   4  (residues 1 to 1644)
  AUTHORS   Smith,D.K. and Xue,H.
  TITLE     Sequence profiles of immunoglobulin and immunoglobulin-like domains
  JOURNAL   J Mol Biol 274 (4), 530-545 (1997)
   PUBMED   9417933
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11457182
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..1644
                     /product="alpha-2-macroglobulin family protein"
                     /GO_function="GO:0004866 - endopeptidase inhibitor
                     activity [Evidence IEA]"
                     /GO_process="GO:0010951 - negative regulation of
                     endopeptidase activity [Evidence IEA]"
                     /calculated_mol_wt=179516
     Region          23..1642
                     /region_name="YfaS"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; COG2373"
                     /db_xref="CDD:441940"
ORIGIN      
        1 mkhlrvvacm imlalagcdn ndktapttks eapavaqpsp aqdpaqlqkl aqqsqgkalt
       61 lldaseaqld gaatlvltfs ipldpeqdfs rvvhvvdkks gsvdgawela pnlkelrlrh
      121 lepervlvvt vdpavkalnn atfgksyekt ittrdvqpsv gfasrgsllp gkiaeglpvm
      181 alnvnhvdvn ffrvkpgsla sfvsqweyrs slsnwesdnl lkmadlvytg rfdlnparnt
      241 reklllplsd ikplqqagvy vavmnqaghy nysnaatlft lsdigvsahr yhnrldiftq
      301 slengaaqsg ieivllndkg qtlaqatsda qghvqleadk aaalllarke eqttlldltl
      361 paldlsefnv agapgyskqf fmfgprdlyr pgetvilngl lrdsdgktlp dqpvklevvk
      421 pdgqvmrtvv sqpenglyrl nypldinapt glwhvrantg dnllrswdfh vedfmperma
      481 lnltaqktpl apadevkfsv vgyylygapa ngntlqgqlf lrplrdavaa lpgfqfgnia
      541 eenlsrslde vqltldkggr gevsaasqwq eahsplqvil qasllesggr pvtrrveqai
      601 wpadtlpgir pqfaakavyd yrtdttvnqp ivdedsnaaf divyanaqge kkavsglqvr
      661 lirerrdyyw nwsesegwqs qfdqkdlveg eqtldlnade tgkvsfpvew gayrlevkap
      721 netvssvrfw agyswqdnsd gsgaarpdrv tlkldkanyr pgdtmklhia apvagkgyam
      781 vessdgplww qaidvpaqgl eltipvdktw nrhdlylstl vvrpgdksrs atpkravgll
      841 hlplgddnrr ldlalespak mrpnqpltvr vkasvkhgem pkqinvlvsa vdsgvlnitd
      901 yatpdpwqaf fgqkrygadi ydiygqvieg qgrlaalrfg gdgddlkrgg kppvnhvnii
      961 aqqaqpitln eqgegvvtlp igdfngelrv maqawtaddf grgeskvvva apviaelnmp
     1021 rflaggdvsr lvldvtnltd rpqtlniala asgllellsq qpqpvnlapg vrttlfvpvr
     1081 alegfgegei qatisglnlp getldaqhkq wqigvrpawp aqtvnsgial apgeswhvpe
     1141 qhlanispat lqgqlllsgk pplnlaryir elkaypygcl eqttsglfpa lytnaaqlqs
     1201 lgitgdsdek rraavdigis rilqmqrdng gfalwdenga eepwltayam dflirageqg
     1261 ysvppeainr gnerllrylq dpgtmlirys dntqastfaa qayaalvlar qqkaplgtlr
     1321 eiwerrsqaa sglplmqlgi alntmgdarr geeaitlaln tprqderqwi adygsslrdn
     1381 almlslleen nlrpdaqnal lsslseqafg qrwlstqenn alflaahsrq asagawqvqt
     1441 sleaqplsgd kaltrnldad qlaalevtnt gsqplwlrld ssgypssape pasnvlqier
     1501 qilgtdgqrk slsslrsgel vlvwltvvad rnvpdalvvd llpaglelen qnladssasl
     1561 pesgsevqnl lnqmqqadiq ymefrddrfv aavvvnegqp vtlvylarav tpgtyqlaqp
     1621 qvesmyapqw ratgasegll ivtp