glucose-1-phosphate thymidylyltransferase RfbA [Escherichia coli].

LOCUS       WP_000676061             293 aa            linear   BCT 09-DEC-2024
ACCESSION   WP_000676061
VERSION     WP_000676061.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 293)
  AUTHORS   Ma,Y., Mills,J.A., Belisle,J.T., Vissa,V., Howell,M., Bowlin,K.,
            Scherman,M.S. and McNeil,M.
  TITLE     Determination of the pathway for rhamnose biosynthesis in
            mycobacteria: cloning, sequencing and expression of the
            Mycobacterium tuberculosis gene encoding
            alpha-D-glucose-1-phosphate thymidylyltransferase
  JOURNAL   Microbiology (Reading) 143 (Pt 3), 937-945 (1997)
   PUBMED   9084178
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01207.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..293
                     /gene="rfbA"
     Protein         1..293
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=32645
     Region          2..287
                     /region_name="rmlA"
                     /note="glucose-1-phosphate thymidylyltransferase, short
                     form; TIGR01207"
                     /db_xref="CDD:130274"
     Site            order(6,8..9,80,83..86,108,144,159..160,170,198)
                     /site_type="active"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133019"
     Site            order(12,15..17,20..21,25..27,29..32,35,60,112..113,
                     135..138,142..143,221..223,227..228,231,234..236,239..240)
                     /site_type="active"
                     /note="tetramer interface [active]"
                     /db_xref="CDD:133019"
ORIGIN      
        1 mkgiilaggs gtrlhpitrg vskqllpiyd kpmiyyplsv lmlagireil iittpedkgy
       61 fqrllgdgse fgiqleyaeq pspdglaqaf iigetflnge psclvlgdni ffgqgfspkl
      121 rhvaarteva tvfgyqvmdp erfgvvefdd nfraisleek pkqpksnwav tglyfydskv
      181 veyakqvkps ergeleitsi nqmyleagnl tvellgrgfa wldtgthdsl ieastfvqtv
      241 ekrqgfkiac leeiawrngw lddegvkraa sslaktgygq yllellrarp rqy