MULTISPECIES: bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA

LOCUS       WP_000670407             550 aa            linear   BCT 11-APR-2022
            [Salmonella].
ACCESSION   WP_000670407
VERSION     WP_000670407.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 550)
  AUTHORS   Krug,U., Patzschke,R., Zebisch,M., Balbach,J. and Strater,N.
  TITLE     Contribution of the two domains of E. coli 5'-nucleotidase to
            substrate specificity and catalysis
  JOURNAL   FEBS Lett 587 (5), 460-466 (2013)
   PUBMED   23333297
REFERENCE   2  (residues 1 to 550)
  AUTHORS   Alves-Pereira,I., Canales,J., Cabezas,A., Cordero,P.M., Costas,M.J.
            and Cameselle,J.C.
  TITLE     CDP-alcohol hydrolase, a very efficient activity of the
            5'-nucleotidase/UDP-sugar hydrolase encoded by the ushA gene of
            Yersinia intermedia and Escherichia coli
  JOURNAL   J Bacteriol 190 (18), 6153-6161 (2008)
   PUBMED   18641143
REFERENCE   3  (residues 1 to 550)
  AUTHORS   Knofel,T. and Strater,N.
  TITLE     X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase
            containing a dimetal catalytic site
  JOURNAL   Nat Struct Biol 6 (5), 448-453 (1999)
   PUBMED   10331872
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007109.1
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09558
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..550
                     /gene="ushA"
     Protein         1..550
                     /product="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     UshA"
                     /EC_number="3.1.3.5"
                     /EC_number="3.6.1.45"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=60426
     Region          1..549
                     /region_name="ushA"
                     /note="bifunctional UDP-sugar hydrolase/5'-nucleotidase
                     periplasmic precursor; Reviewed; PRK09558"
                     /db_xref="CDD:236566"
ORIGIN      
        1 mkflkrgval allaafaltt qpaqayekdk tykitilhtn dhhghfwrse ygeyglaaqk
       61 tlvdsirkev aqeggsvlll sggdintgvp esdlqdaepd frgmnligyd amavgnhefd
      121 npltvlrqqe kwakfpflya niyqkstger lfkpwaiftr qdikiavigl ttddtakign
      181 peyftdiefr kpaeeakvvi qelnmnekpd viiatthmgh ydngdhgsna pgdvemarsl
      241 pagslamivg ghsqdpvcma senkkqvnyv pgtpcapdkq ngiwivqahe wgkyvgradf
      301 efrngemkmv nyqlipvnlk kkvtwdngks ervlytpeia enpqmlsllt pfqnkgkaql
      361 evkigsvngl legdrskvrf vqtnmgrvil aaqiartgad fgvmsgggir dsieagdity
      421 ksvlkvqpfg nivvyadmsg kevvdyltav aqmkpdsgay pqlanvsfva kegkltdlki
      481 kgepvdpakt yrmatlsfna tggdgyprid nkpgyvntgf idaevlkefi qqnspldaaa
      541 ftpngevswl