HigA family addiction module antitoxin [Shigella flexneri].

LOCUS       WP_000617168             131 aa            linear   BCT 25-OCT-2021
ACCESSION   WP_000617168
VERSION     WP_000617168.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 131)
  AUTHORS   Wood,T.L. and Wood,T.K.
  TITLE     The HigB/HigA toxin/antitoxin system of Pseudomonas aeruginosa
            influences the virulence factors pyochelin, pyocyanin, and biofilm
            formation
  JOURNAL   Microbiologyopen 5 (3), 499-511 (2016)
   PUBMED   26987441
REFERENCE   2  (residues 1 to 131)
  AUTHORS   Budde,P.P., Davis,B.M., Yuan,J. and Waldor,M.K.
  TITLE     Characterization of a higBA toxin-antitoxin locus in Vibrio
            cholerae
  JOURNAL   J Bacteriol 189 (2), 491-500 (2007)
   PUBMED   17085558
REFERENCE   3  (residues 1 to 131)
  AUTHORS   Tian,Q.B., Ohnishi,M., Murata,T., Nakayama,K., Terawaki,Y. and
            Hayashi,T.
  TITLE     Specific protein-DNA and protein-protein interaction in the hig
            gene system, a plasmid-borne proteic killer gene system of plasmid
            Rts1
  JOURNAL   Plasmid 45 (2), 63-74 (2001)
   PUBMED   11322821
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02607.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     Protein         1..131
                     /product="HigA family addiction module antitoxin"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /calculated_mol_wt=15131
     Region          25..102
                     /region_name="antidote_HigA"
                     /note="addiction module antidote protein, HigA family;
                     TIGR02607"
                     /db_xref="CDD:274228"
     Site            order(35,39,64)
                     /site_type="other"
                     /note="non-specific DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238045"
     Site            order(38,63)
                     /site_type="active"
                     /note="salt bridge [active]"
                     /db_xref="CDD:238045"
     Site            order(45..46,57,60,64..65)
                     /site_type="other"
                     /note="sequence-specific DNA binding site [nucleotide
                     binding]"
                     /db_xref="CDD:238045"
ORIGIN      
        1 miqyvlaslf tgkqqlktmk qatrkpttpg dillyeylep ldlkinelae llhvhrnrvs
       61 alinnnrklt temafrlakv fdttvdfrln lqaavdlwev ennmrtqeel grietvaeyl
      121 arreerakkv a