MULTISPECIES: glutamate--cysteine ligase [Salmonella].

LOCUS       WP_000611821             518 aa            linear   BCT 25-NOV-2024
ACCESSION   WP_000611821
VERSION     WP_000611821.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 518)
  AUTHORS   Wongsaroj,L., Saninjuk,K., Romsang,A., Duang-Nkern,J.,
            Trinachartvanit,W., Vattanaviboon,P. and Mongkolsuk,S.
  TITLE     Pseudomonas aeruginosa glutathione biosynthesis genes play multiple
            roles in stress protection, bacterial virulence and biofilm
            formation
  JOURNAL   PLoS One 13 (10), e0205815 (2018)
   PUBMED   30325949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 518)
  AUTHORS   Hibi,T., Nii,H., Nakatsu,T., Kimura,A., Kato,H., Hiratake,J. and
            Oda,J.
  TITLE     Crystal structure of gamma-glutamylcysteine synthetase: insights
            into the mechanism of catalysis by a key enzyme for glutathione
            homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 101 (42), 15052-15057 (2004)
   PUBMED   15477603
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01434.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..518
                     /gene="gshA"
     Protein         1..518
                     /product="glutamate--cysteine ligase"
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006750 - glutathione biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=58253
     Region          6..517
                     /region_name="glu_cys_ligase"
                     /note="glutamate--cysteine ligase; TIGR01434"
                     /db_xref="CDD:213621"
ORIGIN      
        1 mipdvsqala wlekhpqalk giqrgleret lrvnadgtla ttghpealgs althkwittd
       61 faeallefit pvdgdiqhml tfmrdlhryt arklgdermw plsmpcyiae gqdielaqyg
      121 tsntgrfktl yreglknryg almqtisgvh ynfslpmafw qakcgvtege aakekisagy
      181 frlirnyyrf gwvipylfga spaicssflq gkpttlpfek tdcgmyylpy atslrlsdlg
      241 ytnksqsnlg itfndlheyv aglkraiktp seeyarigve kdgkrlqins nvlqienely
      301 apirpkrvtr sgespsdall rggieyievr sldinpfspi gvdeqqvrfl dlfmvwcvla
      361 dapemssdel lctrtnwnrv ilegrkpglt lgigcetaqf plpkvgkdlf rdlkrvaqtl
      421 dsihggeeyq kvcdelvacf dnpeltfsar ilrsmidegi ggtgkafgea yrnllreepl
      481 eilqeeefia erdasvrrqq eieaadtepf aawlakha