hydroxymethylbilane synthase [Escherichia coli].

LOCUS       WP_000606154             320 aa            linear   BCT 01-JUL-2024
ACCESSION   WP_000606154
VERSION     WP_000606154.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 320)
  AUTHORS   Louie,G.V., Brownlie,P.D., Lambert,R., Cooper,J.B., Blundell,T.L.,
            Wood,S.P., Malashkevich,V.N., Hadener,A., Warren,M.J. and
            Shoolingin-Jordan,P.M.
  TITLE     The three-dimensional structure of Escherichia coli porphobilinogen
            deaminase at 1.76-A resolution
  JOURNAL   Proteins 25 (1), 48-78 (1996)
   PUBMED   8727319
REFERENCE   2  (residues 1 to 320)
  AUTHORS   Fujino,E., Fujino,T., Karita,S., Sakka,K. and Ohmiya,K.
  TITLE     Cloning and sequencing of some genes responsible for porphyrin
            biosynthesis from the anaerobic bacterium Clostridium josui
  JOURNAL   J Bacteriol 177 (17), 5169-5175 (1995)
   PUBMED   7665501
REFERENCE   3  (residues 1 to 320)
  AUTHORS   Hadener,A., Matzinger,P.K., Malashkevich,V.N., Louie,G.V.,
            Wood,S.P., Oliver,P., Alefounder,P.R., Pitt,A.R., Abell,C. and
            Battersby,A.R.
  TITLE     Purification, characterization, crystallisation and X-ray analysis
            of selenomethionine-labelled hydroxymethylbilane synthase from
            Escherichia coli
  JOURNAL   Eur J Biochem 211 (3), 615-624 (1993)
   PUBMED   8436121
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00212.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..320
                     /gene="hemC"
     Protein         1..320
                     /product="hydroxymethylbilane synthase"
                     /EC_number="2.5.1.61"
                     /GO_function="GO:0004418 - hydroxymethylbilane synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=34499
     Region          11..314
                     /region_name="HemC"
                     /note="Porphobilinogen deaminase [Coenzyme transport and
                     metabolism]; COG0181"
                     /db_xref="CDD:439951"
ORIGIN      
        1 mimtvtsmld nvlriatrqs plalwqahyv kdklmashpg lvvelvpmvt rgdvildtpl
       61 akvggkglfv kelevallen radiavhsmk dvpvefpqgl glvticered prdafvsnny
      121 dsldalpags ivgtsslrrq cqlaerrpdl iirslrgnvg trlskldnge ydaiilavag
      181 lkrlglesri raalppeisl pavgqgavgi ecrlddtrtr ellaalnhhe talrvtaera
      241 mntrleggcq vpigsyaeli dgeiwlralv gapdgsqiir gerrgapqda eqmgislaee
      301 llnngareil aevyngdapa