MULTISPECIES: glutamine-hydrolyzing carbamoyl-phosphate synthase

LOCUS       WP_000597260             382 aa            linear   BCT 04-JUN-2024
            small subunit [Enterobacteriaceae].
ACCESSION   WP_000597260
VERSION     WP_000597260.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J Biol Chem 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01368.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..382
                     /gene="carA"
     Protein         1..382
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=41300
     Region          1..375
                     /region_name="CarA"
                     /note="Carbamoylphosphate synthase small subunit [Amino
                     acid transport and metabolism, Nucleotide transport and
                     metabolism]; COG0505"
                     /db_xref="CDD:440271"
ORIGIN      
        1 miksallvle dgtqfhgrai gatgsavgev vfntsmtgyq eiltdpsysr qivtltyphi
       61 gnvgtndade essqvhaqgl virdlplias nfrntedlss ylkrhnivai adidtrkltr
      121 llrekgaqng ciiagdnpda alalekaraf pglngmdlak evttaeaysw tqgswtltgg
      181 lpeakkedel pfhvvaydfg akrnilrmlv drgcrltivp aqtsaedvlk mnpdgiflsn
      241 gpgdpapcdy aitaiqkfle tdipvfgicl ghqllalasg aktvkmkfgh hggnhpvkdv
      301 eknvvmitaq nhgfavdeat lpanlrvthk slfdgtlqgi hrtdkpafsf qghpeaspgp
      361 hdaaplfdhf ielieqyrkt ak