MULTISPECIES: 6-phosphofructokinase [Salmonella].

LOCUS       WP_000591793             320 aa            linear   BCT 03-JUN-2024
ACCESSION   WP_000591793
VERSION     WP_000591793.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 320)
  AUTHORS   Sakai,H. and Ohta,T.
  TITLE     Molecular cloning and nucleotide sequence of the gene for pyruvate
            kinase of Bacillus stearothermophilus and the production of the
            enzyme in Escherichia coli. Evidence that the genes for
            phosphofructokinase and pyruvate kinase constitute an operon
  JOURNAL   Eur J Biochem 211 (3), 851-859 (1993)
   PUBMED   8436141
REFERENCE   2  (residues 1 to 320)
  AUTHORS   Le Bras,G., Deville-Bonne,D. and Garel,J.R.
  TITLE     Purification and properties of the phosphofructokinase from
            Lactobacillus bulgaricus. A non-allosteric analog of the enzyme
            from Escherichia coli
  JOURNAL   Eur J Biochem 198 (3), 683-687 (1991)
   PUBMED   1828763
REFERENCE   3  (residues 1 to 320)
  AUTHORS   Hellinga,H.W. and Evans,P.R.
  TITLE     Mutations in the active site of Escherichia coli
            phosphofructokinase
  JOURNAL   Nature 327 (6121), 437-439 (1987)
   PUBMED   2953977
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02482.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..320
                     /gene="pfkA"
     Protein         1..320
                     /product="6-phosphofructokinase"
                     /EC_number="2.7.1.11"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /calculated_mol_wt=34784
     Region          2..319
                     /region_name="PRK03202"
                     /note="ATP-dependent 6-phosphofructokinase"
                     /db_xref="CDD:235111"
     Site            order(12,42,73,104..106,108..109,126,128,130,170..172,223,
                     250,253)
                     /site_type="active"
                     /db_xref="CDD:238388"
     Site            order(12,42,73,104..106,108..109)
                     /site_type="other"
                     /note="ADP/pyrophosphate binding site [chemical binding]"
                     /db_xref="CDD:238388"
     Site            order(22,26,55,60,63,136,148,152,155,183..184,186,214,
                     262..263,267,274,289,318..320)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238388"
     Site            order(22,26,55..56,59..60,155,186,188,212,214..216)
                     /site_type="active"
                     /note="allosteric effector site [active]"
                     /db_xref="CDD:238388"
     Site            order(126,128,130,163,170..172,223,244,250,253)
                     /site_type="other"
                     /note="fructose-1,6-bisphosphate binding site"
                     /db_xref="CDD:238388"
ORIGIN      
        1 mikkigvlts ggdapgmnaa irgvvraalt eglevmgiyd gylglyedrm vqldrysvsd
       61 minrggtflg sarfpefrde niravaienl kkrgidalvv iggdgsymga krltemgfpc
      121 iglpgtidnd ikgtdytigy ftalgtvvea idrlrdtsss hqrisivevm grycgdltla
      181 aaiaggcefi vvpevefnre dlvaeikagi akgkkhaiva itehmcdvde lahfieketg
      241 retratvlgh iqrggspvpy drilasrmga yaidlllegh ggrcvgiqne qlvhhdiida
      301 ienmkrpfks dwmecakkly