1-(5-phosphoribosyl)-5-[(5-

LOCUS       WP_000586451             245 aa            linear   BCT 28-AUG-2019
            phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
            isomerase [Escherichia coli].
ACCESSION   WP_000586451
VERSION     WP_000586451.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 245)
  AUTHORS   Barona-Gomez,F. and Hodgson,D.A.
  TITLE     Occurrence of a putative ancient-like isomerase involved in
            histidine and tryptophan biosynthesis
  JOURNAL   EMBO Rep. 4 (3), 296-300 (2003)
   PUBMED   12634849
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00007.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..245
                     /gene="hisA"
     Protein         1..245
                     /product="1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase"
                     /EC_number="5.3.1.16"
                     /GO_function="GO:0003949 -
                     1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=25900
     Region          1..238
                     /region_name="PRK00748"
                     /note="1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]
                     imidazole-4-carboxamide isomerase; Validated"
                     /db_xref="CDD:179108"
     Site            order(7,47,129)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:240083"
ORIGIN      
        1 miipaldlid gtvvrlhqgd ygkqrdygnd plprlqdyaa qgaevlhlvd ltgakdpakr
       61 qipliktlva gvnvpvqvgg gvrseedvaa lleagvarvv vgstavkspe mvkgwferfg
      121 adalvlaldv rideqgnkqv avsgwqensg vsleqlvety lpvglkhvlc tdisrdgtla
      181 gsnvslyeev carypqvafq ssggigdind vaalrgtgvr gvivgralle gkftvkeais
      241 cwqna