bifunctional tetrahydrofolate synthase/dihydrofolate synthase

FASTA View on NCBI
LOCUS       WP_000584553             422 aa            linear   BCT 20-JUN-2019
            [Escherichia coli].
ACCESSION   WP_000584553
VERSION     WP_000584553.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008101.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK10846
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..422
                     /gene="folC"
     Protein         1..422
                     /product="bifunctional tetrahydrofolate
                     synthase/dihydrofolate synthase"
                     /EC_number="6.3.2.12"
                     /EC_number="6.3.2.17"
                     /GO_function="GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /calculated_mol_wt=45267
     Region          1..416
                     /region_name="PRK10846"
                     /note="bifunctional folylpolyglutamate synthase/
                     dihydrofolate synthase; Provisional"
                     /db_xref="CDD:182774"
ORIGIN      
        1 miikrtpqaa splaswlsyl enlhsktidl glervsqvaa rlgvlkpapf vftvagtngk
       61 gttcrtlesi lmaagykvgv yssphlvcyt ervrvqgqel pesahtasfa eiesargdis
      121 ltyfeygtls alwlfkqaql dvvilevglg grldatnivd advavvtsia ldhtdwlgpd
      181 resigrekag ifrsekpaiv gepempstia dvaqekgall qrrgvewnys vtdhdwafsd
      241 ahgtlenlpl plvpqpnaat alaalrasgl evsenairdg iasailpgrf qivsesprvi
      301 fdvahnphaa eyltgrmktl pkngrvlavi gmlhdkdiag tlawlksvvd dwycaplegp
      361 rgataeqlle hlgngksfds vaqawdaama dakaedtvlv cgsfhtvahv mevidarrsg
      421 gk