type II toxin-antitoxin system antitoxin HigA [Escherichia coli].

LOCUS       WP_000560249             138 aa            linear   BCT 20-NOV-2023
ACCESSION   WP_000560249
VERSION     WP_000560249.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 138)
  AUTHORS   Schuessler,D.L., Cortes,T., Fivian-Hughes,A.S., Lougheed,K.E.,
            Harvey,E., Buxton,R.S., Davis,E.O. and Young,D.B.
  TITLE     Induced ectopic expression of HigB toxin in Mycobacterium
            tuberculosis results in growth inhibition, reduced abundance of a
            subset of mRNAs and cleavage of tmRNA
  JOURNAL   Mol. Microbiol. 90 (1), 195-207 (2013)
   PUBMED   23927792
REFERENCE   2  (residues 1 to 138)
  AUTHORS   Bordes,P., Cirinesi,A.M., Ummels,R., Sala,A., Sakr,S., Bitter,W.
            and Genevaux,P.
  TITLE     SecB-like chaperone controls a toxin-antitoxin stress-responsive
            system in Mycobacterium tuberculosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (20), 8438-8443 (2011)
   PUBMED   21536872
REFERENCE   3  (residues 1 to 138)
  AUTHORS   Fivian-Hughes,A.S. and Davis,E.O.
  TITLE     Analyzing the regulatory role of the HigA antitoxin within
            Mycobacterium tuberculosis
  JOURNAL   J. Bacteriol. 192 (17), 4348-4356 (2010)
   PUBMED   20585061
REFERENCE   4  (residues 1 to 138)
  AUTHORS   Christensen-Dalsgaard,M., Jorgensen,M.G. and Gerdes,K.
  TITLE     Three new RelE-homologous mRNA interferases of Escherichia coli
            differentially induced by environmental stresses
  JOURNAL   Mol. Microbiol. 75 (2), 333-348 (2010)
   PUBMED   19943910
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR007583
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..138
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..138
                     /gene="higA"
     Protein         1..138
                     /product="type II toxin-antitoxin system antitoxin HigA"
                     /calculated_mol_wt=14885
     Region          12..138
                     /region_name="HigA"
                     /note="Antitoxin component HigA of the HigAB
                     toxin-antitoxin module, contains an N-terminal HTH domain
                     [Defense mechanisms]; COG5499"
                     /db_xref="CDD:444250"
ORIGIN      
        1 miaiadilha gekltavapf lagiqneeqy iqalelvdhl llndpenpll dlvcakitaw
       61 eesapefaef namaqampgg iavirtlmdq ygltlsdlpe igsksmvsrv lsgkrkltle
      121 hakklatrfg ispalfid