MULTISPECIES: diguanylate cyclase [Enterobacteriaceae].

LOCUS       WP_000558061             472 aa            linear   BCT 03-DEC-2023
ACCESSION   WP_000558061
VERSION     WP_000558061.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11111091
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..472
                     /product="diguanylate cyclase"
                     /EC_number="2.7.7.65"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=52036
     Region          18..>461
                     /region_name="MASE1"
                     /note="Integral membrane sensor domain MASE1 [Signal
                     transduction mechanisms]; COG3447"
                     /db_xref="CDD:442670"
     Region          303..461
                     /region_name="GGDEF"
                     /note="Diguanylate cyclase, GGDEF domain; pfam00990"
                     /db_xref="CDD:425976"
     Site            order(338,381)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(343,346..347,351,355,377,379..382)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(373,401)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 mhvhpistfr vfqeghllrn siaifalttl fyfigaelrl vhelslfwpl ngvmagvfar
       61 yvwlnrlhyy aisyvamlvy daittewglv slainfsnmm fivtvallvv rdkrlgknky
      121 epvsalrlfn ycliaallca ivgaigsvsi dsldfwplla dwfseqfstg vlivpcmltl
      181 aipgvlprfk aeqmmpaial ivsviasvvi ggagslafpl paliwcavry tpqvtclltf
      241 vtgaveivlv ansvidisvg spfsipqmfs arlgiatmai cpimvsfsva ainslmkqva
      301 lradfdfltq vysrsglyea lkspslkqtq hltvmlldid yfksindnyg hecgdkvlsv
      361 farhiqkivg dkglvarmgg eefavavpsv npvdgllmae kirkgvelqp ftwqqktlyl
      421 tvsigvgsgr asyrtltddf nklmveadtc lyrskkdgrn rtstmrygee vv