MULTISPECIES: type II toxin-antitoxin system toxin HigB

LOCUS       WP_000550189             104 aa            linear   BCT 16-DEC-2020
            [Enterobacteriaceae].
ACCESSION   WP_000550189
VERSION     WP_000550189.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 104)
  AUTHORS   Kirkpatrick,C.L., Martins,D., Redder,P., Frandi,A., Mignolet,J.,
            Chapalay,J.B., Chambon,M., Turcatti,G. and Viollier,P.H.
  TITLE     Growth control switch by a DNA-damage-inducible toxin-antitoxin
            system in Caulobacter crescentus
  JOURNAL   Nat Microbiol 1, 16008 (2016)
   PUBMED   27572440
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 104)
  AUTHORS   Schuessler,D.L., Cortes,T., Fivian-Hughes,A.S., Lougheed,K.E.,
            Harvey,E., Buxton,R.S., Davis,E.O. and Young,D.B.
  TITLE     Induced ectopic expression of HigB toxin in Mycobacterium
            tuberculosis results in growth inhibition, reduced abundance of a
            subset of mRNAs and cleavage of tmRNA
  JOURNAL   Mol. Microbiol. 90 (1), 195-207 (2013)
   PUBMED   23927792
REFERENCE   3  (residues 1 to 104)
  AUTHORS   Bordes,P., Cirinesi,A.M., Ummels,R., Sala,A., Sakr,S., Bitter,W.
            and Genevaux,P.
  TITLE     SecB-like chaperone controls a toxin-antitoxin stress-responsive
            system in Mycobacterium tuberculosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (20), 8438-8443 (2011)
   PUBMED   21536872
REFERENCE   4  (residues 1 to 104)
  AUTHORS   Christensen-Dalsgaard,M., Jorgensen,M.G. and Gerdes,K.
  TITLE     Three new RelE-homologous mRNA interferases of Escherichia coli
            differentially induced by environmental stresses
  JOURNAL   Mol. Microbiol. 75 (2), 333-348 (2010)
   PUBMED   19943910
REFERENCE   5  (residues 1 to 104)
  AUTHORS   Ramage,H.R., Connolly,L.E. and Cox,J.S.
  TITLE     Comprehensive functional analysis of Mycobacterium tuberculosis
            toxin-antitoxin systems: implications for pathogenesis, stress
            responses, and evolution
  JOURNAL   PLoS Genet. 5 (12), e1000767 (2009)
   PUBMED   20011113
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR008421
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..104
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..104
                     /gene="higB"
     Protein         1..104
                     /product="type II toxin-antitoxin system toxin HigB"
                     /calculated_mol_wt=11972
     Region          2..92
                     /region_name="HigB"
                     /note="mRNA-degrading endonuclease (mRNA interferase)
                     HigB, toxic component of the HigAB toxin-antitoxin module
                     [Translation, ribosomal structure and biogenesis, Defense
                     mechanisms]; COG4680"
                     /db_xref="CDD:443716"
ORIGIN      
        1 mhlitqkalk daaekypqhk telvalgnti akgyfkkpes lkavfpsldn fkyldkhyvf
       61 nvggnelrvv amvffesqkc yirevmthke ydfftavhrt kgkk