MULTISPECIES: 7-alpha-hydroxysteroid dehydrogenase

LOCUS       WP_000483353             255 aa            linear   BCT 16-DEC-2020
            [Enterobacteriaceae].
ACCESSION   WP_000483353
VERSION     WP_000483353.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF004773.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK06113
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..255
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..255
                     /gene="hdhA"
     Protein         1..255
                     /product="7-alpha-hydroxysteroid dehydrogenase"
                     /EC_number="1.1.1.159"
                     /calculated_mol_wt=26648
     Region          1..255
                     /region_name="PRK06113"
                     /note="7-alpha-hydroxysteroid dehydrogenase; Validated"
                     /db_xref="CDD:135765"
     Site            order(18,20..24,42..43,67..69,95..98,117,144..146,159,163,
                     189..192,194,196..197)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:187623"
     Site            order(98..101,146,148,151,159,189,196..197,209,252)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:187623"
     Site            order(104..106,111..112,115,119..120,123..124,126..127,
                     130,148..157,160..161,164..165,168..169,171..177,182..183,
                     191..192,212,214..215,217..219,223,226..227,229..230,235,
                     238..240,242,244..249,252)
                     /site_type="other"
                     /note="homotetramer interface [polypeptide binding]"
                     /db_xref="CDD:187623"
     Site            order(104..106,111..112,115..116,119..120,123..124,127,
                     148..157,160..161,164..165,168..169,171..173,175..177)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:187623"
     Site            order(118,146,159,163)
                     /site_type="active"
                     /db_xref="CDD:187623"
ORIGIN      
        1 mfnsdnlrld gkcaiitgag agigkeiait fatagasvvv sdinadaanh vvdeiqqlgg
       61 qafacrcdit seqelsalad faisklgkvd ilvnnagggg pkpfdmpmad frrayelnvf
      121 sffhlsqlva pemekngggv iltitsmaae nkninmtsya sskaaashlv rnmafdlgek
      181 nirvngiapg ailtdalksv itpeieqkml qhtpirrlgq pqdianaalf lcspaaswvs
      241 gqiltvsggg vqeln