voltage-gated ClC-type chloride channel ClcB [Shigella flexneri].

LOCUS       WP_000468292             438 aa            linear   BCT 31-MAY-2019
ACCESSION   WP_000468292
VERSION     WP_000468292.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002437.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK01610
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     gene            1..438
                     /gene="clcB"
     Protein         1..438
                     /product="voltage-gated ClC-type chloride channel ClcB"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0010447 - response to acidic pH [Evidence
                     IEA]"
                     /calculated_mol_wt=46651
     Region          21..438
                     /region_name="PRK01610"
                     /note="putative voltage-gated ClC-type chloride channel
                     ClcB; Provisional"
                     /db_xref="CDD:234963"
     Site            order(104..108,138..142,340..344)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238233"
     Site            order(105,107,140..141,340..342)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238233"
     Site            140
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238233"
     Site            order(184,193,208,215,388,391,399,407,414..415)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238233"
ORIGIN      
        1 mfhcpfllmh hlhiypdlrt mfrrlliatv vgilavfava gfrhamllle wlflnndsgs
       61 lvnaatnlss wrrlltpalg glaaglllmg wqkftqqrph aptdymealq tdgqfdyaas
      121 lvkslasllv vtsgsaigre gamillaala ascfaqrftp rqewklwiac gaaagmaaay
      181 raplagslfi aevlfgtmml aslgpviisa ivawlvsnli nhsdallynv qlsvtvqard
      241 yaliistgvl aglcgplllt lmnachrgfv slklappwql algglivgll slftpavwgn
      301 gystvqsflt appllmiiag iflcklcavl assgsgapgg vftptlfigl aigmlygrsl
      361 glwfpdgeei tlllgltgma tllaatthap imstlmicem tgeyqllpgl liacviasvi
      421 srtlhrdsiy rqhtaqhs