MULTISPECIES: aspartate transaminase [Enterobacteriaceae].

LOCUS       WP_000462687             396 aa            linear   BCT 05-JAN-2022
ACCESSION   WP_000462687
VERSION     WP_000462687.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Liu,D., Pozharski,E., Lepore,B.W., Fu,M., Silverman,R.B.,
            Petsko,G.A. and Ringe,D.
  TITLE     Inactivation of Escherichia coli L-aspartate aminotransferase by
            (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals 'a tale
            of two mechanisms'
  JOURNAL   Biochemistry 46 (37), 10517-10527 (2007)
   PUBMED   17713924
REFERENCE   2  (residues 1 to 396)
  AUTHORS   Mahon,M.M., Graber,R., Christen,P. and Malthouse,J.P.
  TITLE     The aspartate aminotransferase-catalysed exchange of the
            alpha-protons of aspartate and glutamate: the effects of the R386A
            and R292V mutations on this exchange reaction
  JOURNAL   Biochim. Biophys. Acta 1434 (1), 191-201 (1999)
   PUBMED   10556573
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR011104
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..396
                     /gene="aspC"
     Protein         1..396
                     /product="aspartate transaminase"
                     /EC_number="2.6.1.1"
                     /calculated_mol_wt=43442
     Region          1..396
                     /region_name="PRK09257"
                     /note="aromatic amino acid transaminase"
                     /db_xref="CDD:181731"
     Site            order(102..104,130,183,214,243,245..246,254)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99734"
     Site            order(105,140,207,252..254,290,293)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:99734"
     Site            246
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99734"
ORIGIN      
        1 mfenitaapa dpilgladlf raderpgkin lgigvykdet gktpvltsvk kaeqyllene
       61 ttknylgidg ipefgrctqe llfgkgsali ndkrartaqt pggtgalrva adflakntsv
      121 krvwvsnpsw pnhksvfnsa glevreyayy daenhtldfd alinslneaq agdvvlfhgc
      181 chnptgidpt leqwqtlaql svekgwlplf dfayqgfarg leedaeglra faamhkeliv
      241 assysknfgl ynervgactl vaadsetvdr afsqmkaair anysnppahg asvvatilsn
      301 dalraiweqe ltdmrqriqr mrqlfvntlq ekganrdfsf iikqngmfsf sgltkeqvlr
      361 lreefgvyav asgrvnvagm tpdnmaplce aivavl