MULTISPECIES: Y-family DNA polymerase [Salmonella].

LOCUS       WP_000457662             422 aa            linear   BCT 28-JUL-2024
ACCESSION   WP_000457662
VERSION     WP_000457662.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Tonzi,P. and Huang,T.T.
  TITLE     Role of Y-family translesion DNA polymerases in replication stress:
            Implications for new cancer therapeutic targets
  JOURNAL   DNA Repair (Amst) 78, 20-26 (2019)
   PUBMED   30954011
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Yang,W.
  TITLE     An overview of Y-Family DNA polymerases and a case study of human
            DNA polymerase eta
  JOURNAL   Biochemistry 53 (17), 2793-2803 (2014)
   PUBMED   24716551
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11480002
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..422
                     /product="Y-family DNA polymerase"
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006974 - DNA damage response [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0019985 - translesion synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0042276 - error-prone translesion
                     synthesis [Evidence IEA]"
                     /calculated_mol_wt=47597
     Region          1..422
                     /region_name="umuC"
                     /note="translesion error-prone DNA polymerase V subunit
                     UmuC; PRK03609"
                     /db_xref="CDD:179607"
     Site            order(6..7,10..11,42,45,101..102,154)
                     /site_type="active"
                     /db_xref="CDD:176454"
     Site            order(99,102,185..191,220,245..250,277,296..300,302)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176454"
ORIGIN      
        1 mfalcdvnsf yascetvfrp dlcgrpvvvl snndgcviac saeakqlgia pgepyfkqke
       61 rfrrsgvvcf ssnyelyadm snrvmttlee mvprveiysi deafcdltgv rncrdltdfg
      121 reiratvlkr thltvgvgia qtktlaklan haakkwqrqt dgvvdlsnid rqrrllalip
      181 vedvwgvgrr iskklnalgi ktaldlseqs twiirkhfnv vlertvrelr gepcleleef
      241 apakqeivcs rsfgervtdy eemrqavysy aaraaeklrg ehqycrfist fvktspfaln
      301 epyygnsaav tlltptqdsr diinaavkcl dkiwrdghry qkagvmlgdf fsqgvaqlnl
      361 fddnaprags aklmevldhl nakdgkgtly fagqgmsqqw amkremlspr yttrysdllr
      421 vk