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LOCUS WP_000443092 268 aa linear BCT 02-JUN-2021 ACCESSION WP_000443092 VERSION WP_000443092.1 KEYWORDS RefSeq. SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 (residues 1 to 268) AUTHORS Dunn,M.F. TITLE Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex JOURNAL Arch Biochem Biophys 519 (2), 154-166 (2012) PUBMED 22310642 REFERENCE 2 (residues 1 to 268) AUTHORS Hyde,C.C., Ahmed,S.A., Padlan,E.A., Miles,E.W. and Davies,D.R. TITLE Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium JOURNAL J Biol Chem 263 (33), 17857-17871 (1988) PUBMED 3053720 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: HMM Evidence Accession :: TIGR00262.1 Evidence Source :: JCVI ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..268 /organism="Escherichia coli" /db_xref="taxon:562" gene 1..268 /gene="trpA" Protein 1..268 /product="tryptophan synthase subunit alpha" /EC_number="4.2.1.20" /GO_function="GO:0004834 - tryptophan synthase activity [Evidence IEA]" /GO_process="GO:0000162 - tryptophan biosynthetic process [Evidence IEA]" /calculated_mol_wt=28594 Region 8..263 /region_name="trpA" /note="tryptophan synthase, alpha subunit; TIGR00262" /db_xref="CDD:161792" Site order(49,60,64,175,183..184,212..213,234..235) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:240075" Site order(49,60,102,183) /site_type="active" /db_xref="CDD:240075" Site order(49,60,102) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:240075" Site order(54..57,59,62,65..66,104,107,129..130,132,135,155, 157..159,162) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:240075" ORIGIN 1 meryeslfaq lkerkegafv pfvtlgdpgi eqslkiidtl ieagadtlel gipfsdplad 61 gptiqnatlr afaagvtpaq cfemlalirq khptipigll myanlvfnkg idefyaqcek 121 vgvdsvlvad vpveesapfr qaalrhnvap ificppnadd dllrqiasyg rgytyllsra 181 gvtgaenraa lplnhlvakl keynaapplq gfgisapdqv kaaidagaag aisgsaivki 241 ieqhinepkk mlaalkafvq pmkaatrs