MULTISPECIES: tryptophan synthase subunit alpha

LOCUS       WP_000443067             268 aa            linear   BCT 02-JUN-2021
            [Enterobacteriaceae].
ACCESSION   WP_000443067
VERSION     WP_000443067.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 268)
  AUTHORS   Dunn,M.F.
  TITLE     Allosteric regulation of substrate channeling and catalysis in the
            tryptophan synthase bienzyme complex
  JOURNAL   Arch Biochem Biophys 519 (2), 154-166 (2012)
   PUBMED   22310642
REFERENCE   2  (residues 1 to 268)
  AUTHORS   Hyde,C.C., Ahmed,S.A., Padlan,E.A., Miles,E.W. and Davies,D.R.
  TITLE     Three-dimensional structure of the tryptophan synthase alpha 2 beta
            2 multienzyme complex from Salmonella typhimurium
  JOURNAL   J Biol Chem 263 (33), 17857-17871 (1988)
   PUBMED   3053720
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00262.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..268
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..268
                     /gene="trpA"
     Protein         1..268
                     /product="tryptophan synthase subunit alpha"
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=28593
     Region          8..263
                     /region_name="trpA"
                     /note="tryptophan synthase, alpha subunit; TIGR00262"
                     /db_xref="CDD:161792"
     Site            order(49,60,64,175,183..184,212..213,234..235)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:240075"
     Site            order(49,60,102,183)
                     /site_type="active"
                     /db_xref="CDD:240075"
     Site            order(49,60,102)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:240075"
     Site            order(54..57,59,62,65..66,104,107,129..130,132,135,155,
                     157..159,162)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240075"
ORIGIN      
        1 meryeslfaq lkerkegafv pfvtlgdpgi eqslkiidtl ieagadalel gipfsdplad
       61 gptiqnatlr afaagvtpaq cfemlalirq khptipigll myanlvfnkg idefyaqcek
      121 vgvdsvlvad vpveesapfr qaalrhnvap ificppnadd dllrqiasyg rgytyllsra
      181 gvtgaenraa lplnhlvakl keynaapplq gfgisapdqv kaaidagaag aisgsaivki
      241 ieqhinepek mlaalkvfvq pmkaatrs