MULTISPECIES: tryptophan synthase subunit alpha [Salmonella].

LOCUS       WP_000443030             268 aa            linear   BCT 02-JUN-2021
ACCESSION   WP_000443030
VERSION     WP_000443030.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 268)
  AUTHORS   Dunn,M.F.
  TITLE     Allosteric regulation of substrate channeling and catalysis in the
            tryptophan synthase bienzyme complex
  JOURNAL   Arch Biochem Biophys 519 (2), 154-166 (2012)
   PUBMED   22310642
REFERENCE   2  (residues 1 to 268)
  AUTHORS   Hyde,C.C., Ahmed,S.A., Padlan,E.A., Miles,E.W. and Davies,D.R.
  TITLE     Three-dimensional structure of the tryptophan synthase alpha 2 beta
            2 multienzyme complex from Salmonella typhimurium
  JOURNAL   J Biol Chem 263 (33), 17857-17871 (1988)
   PUBMED   3053720
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00262.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..268
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..268
                     /gene="trpA"
     Protein         1..268
                     /product="tryptophan synthase subunit alpha"
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=28540
     Region          8..263
                     /region_name="trpA"
                     /note="tryptophan synthase, alpha subunit; TIGR00262"
                     /db_xref="CDD:161792"
     Site            order(49,60,64,175,183..184,212..213,234..235)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:240075"
     Site            order(49,60,102,183)
                     /site_type="active"
                     /db_xref="CDD:240075"
     Site            order(49,60,102)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:240075"
     Site            order(54..57,59,62,65..66,104,107,129..130,132,135,155,
                     157..159,162)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240075"
ORIGIN      
        1 meryenlfaq lndrregafv pfvtlgdpgi eqslkiidtl idagadalel gvpfsdplad
       61 gptiqnanlr afaagvtpaq cfemlalire khptipigll myanlvfnng idafyarceq
      121 vgvdsvlvad vpveesapfr qaalrhniap ificppnadd dllrqvasyg rgytyllsrs
      181 gvtgaenrga lplhhliekl keyhaapalq gfgisspeqv saavragaag aisgsaivki
      241 ieknlaspkq mlaelrsfvs amkaasra