MULTISPECIES: MFS transporter [Enterobacteriaceae].

LOCUS       WP_000438807             452 aa            linear   BCT 02-JAN-2025
ACCESSION   WP_000438807
VERSION     WP_000438807.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..452
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=50187
     Region          24..435
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(34..35,38..39,42,74,124..125,127..129,132,152,
                     155..156,159,270,273..274,277..279,282,309,313,363..364,
                     368,372,388,391..392,395..396,399)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 meqydqigar ldrlplarfh yrifgiisfs llltgflsys gnvvlaklvs ngwsnnflna
       61 aftsalmfgy figsltggfi gdyfgrrraf rinllivgia atgaafvpdm ywliffrflm
      121 gtgmgalimv gyasftefip atvrgkwsar lsfvgnwspm lsaaigvvvi affswrimfl
      181 lggigillaw flsgkyfies prwlagkgqi agaecqlrev eqqiereksi rlppltsyqs
      241 nskvkvikgt fwllfkgeml rrtlvaitvl iamnislyti tvwiptifvn sgidvdksil
      301 mtavimigap vgifiaalii dhfprrlfgs tlliiiavlg yiysiqttew ailiyglvmi
      361 fflymyvcfa savyipelwp thlrlrgsgf vnavgrivav ftpygvaall thygsitvfm
      421 vlgvmlllca lvlsifgiet rkvsleeise vn