MULTISPECIES: diguanylate cyclase DosC [Enterobacteriaceae].

LOCUS       WP_000426292             460 aa            linear   BCT 10-JUL-2019
ACCESSION   WP_000426292
VERSION     WP_000426292.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 460)
  AUTHORS   Kitanishi,K., Kobayashi,K., Kawamura,Y., Ishigami,I., Ogura,T.,
            Nakajima,K., Igarashi,J., Tanaka,A. and Shimizu,T.
  TITLE     Important roles of Tyr43 at the putative heme distal side in the
            oxygen recognition and stability of the Fe(II)-O2 complex of YddV,
            a globin-coupled heme-based oxygen sensor diguanylate cyclase
  JOURNAL   Biochemistry 49 (49), 10381-10393 (2010)
   PUBMED   21067162
REFERENCE   2  (residues 1 to 460)
  AUTHORS   Tuckerman,J.R., Gonzalez,G., Sousa,E.H., Wan,X., Saito,J.A.,
            Alam,M. and Gilles-Gonzalez,M.A.
  TITLE     An oxygen-sensing diguanylate cyclase and phosphodiesterase couple
            for c-di-GMP control
  JOURNAL   Biochemistry 48 (41), 9764-9774 (2009)
   PUBMED   19764732
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR007785
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..460
                     /gene="dosC"
     Protein         1..460
                     /product="diguanylate cyclase DosC"
                     /EC_number="2.7.7.65"
                     /calculated_mol_wt=53047
     Region          7..153
                     /region_name="GS_EcDosC-like_GGDEF"
                     /note="Globin sensor domain of Escherichia coli Direct
                     Oxygen Sensing Cyclase and related proteins; coupled to a
                     C-terminal GGDEF domain; cd14757"
                     /db_xref="CDD:381271"
     Site            order(13..15,45,105..107,109..110,113,116,137..138,
                     141..142,145,149)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381271"
     Site            order(52,55,65,68..69,72,94,97..98,103,107,111..112,151)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:381271"
     Region          297..452
                     /region_name="GGDEF"
                     /note="Diguanylate cyclase, GGDEF domain; pfam00990"
                     /db_xref="CDD:425976"
     Site            order(333,376)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(338,341..342,346,350,372,374..377)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(368,396)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 memyfkrmkd ewtglveqad ppirakaaei avahahylsi efyrivridp haeeflsneq
       61 verqlksame rwiinvlsaq vddverliqi qhtvaevhar igipveivem gfrvlkkily
      121 pvifssdysa aeklqvyhfs insidiamev mtraftfsds saskedenyr ifsllenaee
      181 ekerqiasil sweidiiyki lldsdlgssl plsqadfglw fnhkgrhyfs giaevghisr
      241 liqdfdgifn qtmrntrnln nrslrvkfll qirntvsqii tllrelfeev srhevgmdvl
      301 tkllnrrflp tifkreiaha nrtgtplsvl iidvdkfkei ndtwghntgd eilrkvsqaf
      361 ydnvrssdyv fryggdefii vlteasenet lrtaerirsr vektklkaan gedialslsi
      421 gaamfnghpd yerliqiade alyiakrrgr nrvelwkasl