MULTISPECIES: MFS transporter [Salmonella].

LOCUS       WP_000416127             457 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000416127
VERSION     WP_000416127.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..457
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48006
     Region          21..451
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(28..29,32..33,36,68,118..119,121..123,126,146,
                     149..150,153,277,280..281,284..286,289,317,321,373..374,
                     378,382,398,401..402,405..406,409)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mektradglp lpqrygailt iiigismavl dgaianvalp tiatdlhasp assiwivnay
       61 qiaivvslls lsflgdmfgy hriykcglvv fllsslfcal sdslqmltla riaqgfggaa
      121 lmsvntalir liypqrhlgr gmginsfiva vssaagptia aailsisswk wlflinvplg
      181 iialilairf lpaniahdtk prfdlpsavm naltfgllit alsgfaqgqs ltligaellv
      241 lvvvgfffvr rqlslpvpll pidllriplf slsigtsics fcaqmlamvs lpfylqtvlg
      301 rsevetglll tpwplatmvm aplagylier lhagllgalg mvimaaglfa lvmlpaspsd
      361 lniiwpmilc gagfglfqsp nnhtiitsap rersggasgm lgtarllgqs tgaalvalml
      421 nqfgdsgthl sllaaailai laavvsglri tqprvqa