MULTISPECIES: MFS transporter [Enterobacteriaceae].

LOCUS       WP_000410140             453 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000410140
VERSION     WP_000410140.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022908
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..453
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49313
     Region          44..442
                     /region_name="MFS_ExuT_GudP_like"
                     /note="Hexuronate transporter, Glucarate transporter, and
                     similar transporters of the Major Facilitator Superfamily;
                     cd17319"
                     /db_xref="CDD:340877"
     Site            order(54..55,58..59,62,94,144..145,147..149,152,172,
                     175..176,179,266,269..270,273..275,278,306,310,368..369,
                     373,377,393,396..397,400..401,404)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340877"
ORIGIN      
        1 mekenitldp rssftpsssa dipvppdglv qrstrikriq ttamlllffa avinyldrss
       61 lsvanltire elglsateig allsvfslay giaqlpcgpl ldrkgprlml glgmffwslf
      121 qamsgmvhsf tqfvlvrigm gigeapmnpc gvkvindwfn ikergrpmgf fnaastigva
      181 vsppilaamm lvmgwrgmfi tigvlgifla igwymlyrnr ehveltaveq aylnagsvna
      241 rrdplsfaew rslfrnrtmw gmmlgfsgin ytawlylawl pgylqtaynl dlkstglmaa
      301 ipflfgaagm lvngyvtdwl vkggmapiks rkiciiagmf csaaftlivp qattsmmavl
      361 ligmalfcih fagtscwgli hvavasrmta svgsiqnfas ficasfapii tgfivdtths
      421 frlaliicgc vtaagalayi flvrqpindp rkd