MULTISPECIES: GGDEF domain-containing protein [Enterobacteriaceae].

LOCUS       WP_000409873             452 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_000409873
VERSION     WP_000409873.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Simm,R., Fetherston,J.D., Kader,A., Romling,U. and Perry,R.D.
  TITLE     Phenotypic convergence mediated by GGDEF-domain-containing proteins
  JOURNAL   J Bacteriol 187 (19), 6816-6823 (2005)
   PUBMED   16166544
  REMARK    Erratum:[J Bacteriol. 2006 Mar;188(5):2024]
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 12182187
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     Protein         1..452
                     /product="GGDEF domain-containing protein"
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=51652
     Region          43..275
                     /region_name="MASE4"
                     /note="Membrane-associated sensor, integral membrane
                     domain; pfam17158"
                     /db_xref="CDD:435755"
     Region          282..439
                     /region_name="GGDEF"
                     /note="Diguanylate cyclase, GGDEF domain; pfam00990"
                     /db_xref="CDD:425976"
     Site            order(318,361)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(323,326..327,331,335,357,359..362)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(353,381)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 mekdylriss tvlvsllfgl alvlvnswfn qpgveevvpr stylmvmial ffidtvafif
       61 mqlyfiydrr qfsncvlsla flscliyfvi tviiiqqiie erltssvvqn diaiyylfrq
      121 mslcilifla lvnkvsentk qrnlfskkmt lcislffvfg gpivahilss hyesynlhia
      181 eltnengqvv wkasyvtimi fmwltllsvn lyfnglrydi wngvtviafc avlynisllf
      241 msrysvstwy isrtievvsk ltvmvifmch ifsalrvtkn iahrdpltni fnrnyffnel
      301 tvqsasaqkt pycvmimdid hfkkvndtwg hpvgdqvikt vvniigksir pddllarvgg
      361 eefgvlltdi dterakalae rirenverlt gdnpeyaipq kvtisigavv tqenalnpne
      421 iyrladnaly eaketgrnkv vvrdvvnfce sp