GGDEF domain-containing protein [Escherichia coli].

LOCUS       WP_000409847             452 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000409847
VERSION     WP_000409847.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Simm,R., Fetherston,J.D., Kader,A., Romling,U. and Perry,R.D.
  TITLE     Phenotypic convergence mediated by GGDEF-domain-containing proteins
  JOURNAL   J Bacteriol 187 (19), 6816-6823 (2005)
   PUBMED   16166544
  REMARK    Erratum:[J Bacteriol. 2006 Mar;188(5):2024]
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 12182187
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..452
                     /product="GGDEF domain-containing protein"
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=51511
     Region          43..275
                     /region_name="MASE4"
                     /note="Membrane-associated sensor, integral membrane
                     domain; pfam17158"
                     /db_xref="CDD:435755"
     Region          282..439
                     /region_name="GGDEF"
                     /note="Diguanylate cyclase, GGDEF domain; pfam00990"
                     /db_xref="CDD:425976"
     Site            order(318,361)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(323,326..327,331,335,357,359..362)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(353,381)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 mekdylriss tvlvsllfgl alvlvnswfn qpgveevvpr stylmvmial ffidtvafif
       61 mqlyfiydrr qfsncilsla flscliyfvk tviiiqqiie grltssvvqn diaiyylfrq
      121 mslcilifla lvnkvsentk qrnlfskkmt lcislffvfg gaivahilss hyesynlhia
      181 eltnengqvv wkasyvtimi fmwltllsvn lyfnglrydi wngvtviafc avlynisllf
      241 msrysvstwy isrtievvsk ltvmvifmch ifsalrvtkn iahrdpltni fnrnyffnel
      301 tvqsasakkt pycvmimdid hfkkvndtwg hpvgdqvikt vvniigksir pddllarvgg
      361 eefgvlltdi dterakalae rirenverlt gdnpeyaipq kvtisigavv tqgnalnpne
      421 iyrladnaly eaketgrnkv vvrdvvnfce sp