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LOCUS WP_000391998 453 aa linear BCT 21-JAN-2025 ACCESSION WP_000391998 VERSION WP_000391998.1 KEYWORDS RefSeq. SOURCE Vibrio cholerae ORGANISM Vibrio cholerae Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. REFERENCE 1 (residues 1 to 453) AUTHORS Wen,Y., Behiels,E., Felix,J., Elegheert,J., Vergauwen,B., Devreese,B. and Savvides,S.N. TITLE The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence JOURNAL Nucleic Acids Res 42 (15), 10134-10147 (2014) PUBMED 25056321 REFERENCE 2 (residues 1 to 453) AUTHORS Germain,E., Castro-Roa,D., Zenkin,N. and Gerdes,K. TITLE Molecular mechanism of bacterial persistence by HipA JOURNAL Mol Cell 52 (2), 248-254 (2013) PUBMED 24095282 REFERENCE 3 (residues 1 to 453) AUTHORS Kaspy,I., Rotem,E., Weiss,N., Ronin,I., Balaban,N.Q. and Glaser,G. TITLE HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase JOURNAL Nat Commun 4, 3001 (2013) PUBMED 24343429 REFERENCE 4 (residues 1 to 453) AUTHORS Schumacher,M.A., Piro,K.M., Xu,W., Hansen,S., Lewis,K. and Brennan,R.G. TITLE Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB JOURNAL Science 323 (5912), 396-401 (2009) PUBMED 19150849 REFERENCE 5 (residues 1 to 453) AUTHORS Jayaraman,R. TITLE Bacterial persistence: some new insights into an old phenomenon JOURNAL J Biosci 33 (5), 795-805 (2008) PUBMED 19179767 REFERENCE 6 (residues 1 to 453) AUTHORS Black,D.S., Kelly,A.J., Mardis,M.J. and Moyed,H.S. TITLE Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis JOURNAL J Bacteriol 173 (18), 5732-5739 (1991) PUBMED 1715862 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11466423 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..453 /organism="Vibrio cholerae" /db_xref="taxon:666" Protein 1..453 /product="type II toxin-antitoxin system HipA family toxin" /EC_number="2.7.11.1" /GO_component="GO:0110001 - toxin-antitoxin complex [Evidence IEA]" /GO_function="GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]" /GO_process="GO:0016310 - phosphorylation [Evidence IEA]" /calculated_mol_wt=51234 Region 5..441 /region_name="HipA" /note="Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module [Signal transduction mechanisms]; COG3550" /db_xref="CDD:442771" ORIGIN 1 meeltvqafi rgewidigii sfpkssqhnf rvtelnylsd yalehydkdd fhavslnhpv 61 sfffddmgkp gwlkflddim psgasrrywv khldiedlss deqdyvllkf gtmspignlr 121 ikdslperye vadnlyfsvd dvknragdfl dyaqqrgaaa ggatgaggea pklilrcgfd 181 hgsgsekiwi dpyqddnsnh dlhylvkypr gsrstidcni lraefyfyhe ltemgvetis 241 tdgmrleegl nypslwlprf dvqiidqqie rfgmesvysi lnkgagvtld hettirtlie 301 kitesnmvkh qgyrfdtqaf viewvkrdll nilfgnsdnh grntsflkgd gviklapiyd 361 fapmkadpeg iprttkwkap levggtydfv giadtlsdlv pkemllkela itaskcvglk 421 qrlalrgvpe qilempavgl nylsekltkw gll