MFS transporter [Escherichia coli].

LOCUS       WP_000372139             459 aa            linear   BCT 02-JAN-2025
ACCESSION   WP_000372139
VERSION     WP_000372139.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..459
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=49496
     Region          25..426
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(35..36,39..40,43,75,125..126,128..130,133,153,
                     156..157,160,273,276..277,280..282,285,312,316,366..367,
                     371,375,391,394..395,398..399,402)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mdqitkphcg arldrlpdcr whssmfaiva fgllvcwsna vgglilaqlk algwtdnstt
       61 atfsaittag mflgalvggi igdktgrrna filyeaihia smvvgafspn mdfliacrfv
      121 mgvglgallv tlfagfteym pgrnrgtwss rvsfignwsy plcsliamgl tplisaewnw
      181 rvqllipail sliatalawr yfpesprwle srgryqeaek vmrsieegvi rhtgkplppv
      241 viaddgkapq avpysalltg vllkrvilgs cvliamnvvq ytlinwlpti fmtqginlkd
      301 sivlntmsmf gtpfgifiam lvmdkiprkt mgvgllilia vlgyiyslqt smllitligf
      361 flitfvymyv cyasavyvpe iwpteaklrg sglanavgri sgiaapyava vllssygvtg
      421 vfillgavsi ivaiaiatig ietkgvsves lsidavank