MULTISPECIES: type II toxin-antitoxin system death-on-curing family

LOCUS       WP_000351251             133 aa            linear   BCT 19-FEB-2025
            toxin [Vibrio].
ACCESSION   WP_000351251
VERSION     WP_000351251.1
KEYWORDS    RefSeq.
SOURCE      Vibrio
  ORGANISM  Vibrio
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Vibrionales; Vibrionaceae.
REFERENCE   1  (residues 1 to 133)
  AUTHORS   Cruz,J.W., Rothenbacher,F.P., Maehigashi,T., Lane,W.S., Dunham,C.M.
            and Woychik,N.A.
  TITLE     Doc toxin is a kinase that inactivates elongation factor Tu
  JOURNAL   J Biol Chem 289 (11), 7788-7798 (2014)
   PUBMED   24448800
  REMARK    Erratum:[J Biol Chem. 2014 Jul 11;289(28):19276]
REFERENCE   2  (residues 1 to 133)
  AUTHORS   Castro-Roa,D., Garcia-Pino,A., De Gieter,S., van Nuland,N.A.J.,
            Loris,R. and Zenkin,N.
  TITLE     The Fic protein Doc uses an inverted substrate to phosphorylate and
            inactivate EF-Tu
  JOURNAL   Nat Chem Biol 9 (12), 811-817 (2013)
   PUBMED   24141193
REFERENCE   3  (residues 1 to 133)
  AUTHORS   Van Melderen,L. and Saavedra De Bast,M.
  TITLE     Bacterial toxin-antitoxin systems: more than selfish entities?
  JOURNAL   PLoS Genet 5 (3), e1000437 (2009)
   PUBMED   19325885
REFERENCE   4  (residues 1 to 133)
  AUTHORS   Garcia-Pino,A., Christensen-Dalsgaard,M., Wyns,L., Yarmolinsky,M.,
            Magnuson,R.D., Gerdes,K. and Loris,R.
  TITLE     Doc of prophage P1 is inhibited by its antitoxin partner Phd
            through fold complementation
  JOURNAL   J Biol Chem 283 (45), 30821-30827 (2008)
   PUBMED   18757857
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10007658
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..133
                     /organism="Vibrio"
                     /db_xref="taxon:662"
     Protein         1..133
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0090729 - toxin activity [Evidence IEA]"
                     /calculated_mol_wt=14444
     Region          9..121
                     /region_name="Doc"
                     /note="Prophage maintenance system killer protein
                     [Mobilome: prophages, transposons]; COG3654"
                     /db_xref="CDD:442871"
ORIGIN      
        1 mdiicfpfer vieinalilk tepgmkgavd ipklqgalgr idnaivyegl ddvfeiaaky
       61 taciavshal pdankrtgla valeylslnd feltqendll adavrdlvig iinetdfadi
      121 lyaqyakeqn sal