MULTISPECIES: substrate-binding domain-containing protein

LOCUS       WP_000290692             335 aa            linear   BCT 31-AUG-2024
            [Salmonella].
ACCESSION   WP_000290692
VERSION     WP_000290692.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 335)
  AUTHORS   Swint-Kruse,L. and Matthews,K.S.
  TITLE     Allostery in the LacI/GalR family: variations on a theme
  JOURNAL   Curr Opin Microbiol 12 (2), 129-137 (2009)
   PUBMED   19269243
REFERENCE   2  (residues 1 to 335)
  AUTHORS   Fukami-Kobayashi,K., Tateno,Y. and Nishikawa,K.
  TITLE     Parallel evolution of ligand specificity between LacI/GalR family
            repressors and periplasmic sugar-binding proteins
  JOURNAL   Mol Biol Evol 20 (2), 267-277 (2003)
   PUBMED   12598694
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF024770.5
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF13377.11
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..335
                     /product="substrate-binding domain-containing protein"
                     /calculated_mol_wt=35857
     Region          9..74
                     /region_name="HTH_LACI"
                     /note="helix_turn _helix lactose operon repressor;
                     smart00354"
                     /db_xref="CDD:197675"
     Site            order(20..24,26..27,30,35..36,39,52,55,58..59,61..62)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143331"
     Site            52..61
                     /site_type="active"
                     /note="domain linker motif [active]"
                     /db_xref="CDD:143331"
     Region          68..332
                     /region_name="PBP1_LacI-like"
                     /note="ligand-binding domain of uncharacterized
                     DNA-binding regulatory proteins that are members of the
                     LacI-GalR family of bacterial transcription repressors;
                     cd06287"
                     /db_xref="CDD:380510"
     Site            order(68,89..91,94..95,97..98,105..109,111,113,116,
                     119..121,227,255,259,262..263)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:380510"
     Site            order(88..89,92,128,151,165,201,222,278,295)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:380510"
ORIGIN      
        1 mavqnkkrak lidvarhagv spgtvsnalh ntrfvepqtr rrieeaiaal nytpnirarq
       61 lrtgktntia llssvplaia sgasrlgfmm evaltsamma lekqhalilv ppganpldav
      121 sfdaailiep aendpqlqal aqagipcvti grtpgtdtpv pwvelhsaat aqlllthlet
      181 sgaskcalfv gntrrtsvle seaayqrwca grqapvvysl nesegenagy qaaqqllqah
      241 pdvdgvlvli dtfasgavra fqeqavaipe rmrvvtrydg irareslppl tavnmhldev
      301 arqaitllfa vlsgekisys dgimpelvvr astcr