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MULTISPECIES: SPI-1 type III secretion system effector SipA


LOCUS       WP_000258811             685 aa            linear   BCT 10-SEP-2020
            [Salmonella].
ACCESSION   WP_000258811
VERSION     WP_000258811.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 685)
  AUTHORS   Kroger,C., Dillon,S.C., Cameron,A.D., Papenfort,K.,
            Sivasankaran,S.K., Hokamp,K., Chao,Y., Sittka,A., Hebrard,M.,
            Handler,K., Colgan,A., Leekitcharoenphon,P., Langridge,G.C.,
            Lohan,A.J., Loftus,B., Lucchini,S., Ussery,D.W., Dorman,C.J.,
            Thomson,N.R., Vogel,J. and Hinton,J.C.
  TITLE     The transcriptional landscape and small RNAs of Salmonella enterica
            serovar Typhimurium
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (20), E1277-E1286 (2012)
   PUBMED   22538806
REFERENCE   2  (residues 1 to 685)
  AUTHORS   Lilic,M., Vujanac,M. and Stebbins,C.E.
  TITLE     A common structural motif in the binding of virulence factors to
            bacterial secretion chaperones
  JOURNAL   Mol. Cell 21 (5), 653-664 (2006)
   PUBMED   16507363
REFERENCE   3  (residues 1 to 685)
  AUTHORS   McGhie,E.J., Hayward,R.D. and Koronakis,V.
  TITLE     Control of actin turnover by a salmonella invasion protein
  JOURNAL   Mol. Cell 13 (4), 497-510 (2004)
   PUBMED   14992720
REFERENCE   4  (residues 1 to 685)
  AUTHORS   Lilic,M., Galkin,V.E., Orlova,A., VanLoock,M.S., Egelman,E.H. and
            Stebbins,C.E.
  TITLE     Salmonella SipA polymerizes actin by stapling filaments with
            nonglobular protein arms
  JOURNAL   Science 301 (5641), 1918-1921 (2003)
   PUBMED   14512630
REFERENCE   5  (residues 1 to 685)
  AUTHORS   McGhie,E.J., Hayward,R.D. and Koronakis,V.
  TITLE     Cooperation between actin-binding proteins of invasive Salmonella:
            SipA potentiates SipC nucleation and bundling of actin
  JOURNAL   EMBO J. 20 (9), 2131-2139 (2001)
   PUBMED   11331579
REFERENCE   6  (residues 1 to 685)
  AUTHORS   Zhao,L., Ezak,T., Li,Z.Y., Kawamura,Y., Hirose,K. and Watanabe,H.
  TITLE     Vi-Suppressed wild strain Salmonella typhi cultured in high
            osmolarity is hyperinvasive toward epithelial cells and destructive
            of Peyer's patches
  JOURNAL   Microbiol. Immunol. 45 (2), 149-158 (2001)
   PUBMED   11293481
REFERENCE   7  (residues 1 to 685)
  AUTHORS   Zhou,D., Mooseker,M.S. and Galan,J.E.
  TITLE     An invasion-associated Salmonella protein modulates the
            actin-bundling activity of plastin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (18), 10176-10181 (1999)
   PUBMED   10468582
REFERENCE   8  (residues 1 to 685)
  AUTHORS   Zhou,D., Mooseker,M.S. and Galan,J.E.
  TITLE     Role of the S. typhimurium actin-binding protein SipA in bacterial
            internalization
  JOURNAL   Science 283 (5410), 2092-2095 (1999)
   PUBMED   10092234
REFERENCE   9  (residues 1 to 685)
  AUTHORS   Arricau,N., Hermant,D., Waxin,H. and Popoff,M.Y.
  TITLE     Molecular characterization of the Salmonella typhi StpA protein
            that is related to both Yersinia YopE cytotoxin and YopH tyrosine
            phosphatase
  JOURNAL   Res. Microbiol. 148 (1), 21-26 (1997)
   PUBMED   9404501
REFERENCE   10 (residues 1 to 685)
  AUTHORS   Kaniga,K., Trollinger,D. and Galan,J.E.
  TITLE     Identification of two targets of the type III protein secretion
            system encoded by the inv and spa loci of Salmonella typhimurium
            that have homology to the Shigella IpaD and IpaA proteins
  JOURNAL   J. Bacteriol. 177 (24), 7078-7085 (1995)
   PUBMED   8522512
REFERENCE   11 (residues 1 to 685)
  AUTHORS   Hueck,C.J., Hantman,M.J., Bajaj,V., Johnston,C., Lee,C.A. and
            Miller,S.I.
  TITLE     Salmonella typhimurium secreted invasion determinants are
            homologous to Shigella Ipa proteins
  JOURNAL   Mol. Microbiol. 18 (3), 479-490 (1995)
   PUBMED   8748032
REFERENCE   12 (residues 1 to 685)
  AUTHORS   Hermant,D., Menard,R., Arricau,N., Parsot,C. and Popoff,M.Y.
  TITLE     Functional conservation of the Salmonella and Shigella effectors of
            entry into epithelial cells
  JOURNAL   Mol. Microbiol. 17 (4), 781-789 (1995)
   PUBMED   8801431
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR000646
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..685
                     /gene="sipA"
     Protein         1..685
                     /product="SPI-1 type III secretion system effector SipA"
                     /calculated_mol_wt=73811
     Region          16..685
                     /region_name="PRK15376"
                     /note="type III secretion system effector SipA"
                     /db_xref="CDD:185274"
ORIGIN      
        1 mvtsvrtqpp vimpgmqtei ktqatnlaan lsavresata tlsgeikgpq ledfpalikq
       61 asldalfkcg kdaealkevf tnsnnvagkk aimefaglfr salnatsdsp eaktllmkvg
      121 aeytaqiikd glkeksafgp wlpetkkaea klenlekqll diiknntgge lsklstnlvm
      181 qevmpyiasc iehnfgctld pltrsnlthl vdkaaakave aldmchqklt qeqgtsvgre
      241 arhlemqtli plllrnvfaq ipadklpdpk ipepaagpvp dggkkaeptg inininidss
      301 nhsvdnskhi nnsrshvdns qrhidnsnhd nsrktidnsr tfidnsqrng eshhstnssn
      361 vshshsrvds tthqtetahs astgaidhgi agkidvtaha taeavtnass eskdgkvvts
      421 ekgttgetts fdevdgvtsk siigkpvqat vhgvddnkqq sqtaeivnvk plasqlagve
      481 nvktdtlqsd ttvitgnkag ttdndnsqtd ktgpfsglkf kqnsflstvp svtnmhsmhf
      541 daretflgvi rkalepdtst pfpvrrafdg lraeilpndt iksaalkaqc sdidkhpelk
      601 akmetlkevi thhpqkekla eialqfarea gltrlkgetd yvlsnvldgl igdgswragp
      661 ayesylnkpg vdrvittvdg lhmqr