MULTISPECIES: type II toxin-antitoxin system PemK/MazF family toxin

LOCUS       WP_000237588             121 aa            linear   BCT 01-JAN-2025
            [Shigella].
ACCESSION   WP_000237588
VERSION     WP_000237588.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 121)
  AUTHORS   Hall,A.M., Gollan,B. and Helaine,S.
  TITLE     Toxin-antitoxin systems: reversible toxicity
  JOURNAL   Curr Opin Microbiol 36, 102-110 (2017)
   PUBMED   28279904
REFERENCE   2  (residues 1 to 121)
  AUTHORS   Cook,G.M., Robson,J.R., Frampton,R.A., McKenzie,J., Przybilski,R.,
            Fineran,P.C. and Arcus,V.L.
  TITLE     Ribonucleases in bacterial toxin-antitoxin systems
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 523-531 (2013)
   PUBMED   23454553
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10006385
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..121
                     /organism="Shigella"
                     /db_xref="taxon:620"
     Protein         1..121
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /GO_process="GO:0016075 - rRNA catabolic process [Evidence
                     IEA]"
                     /calculated_mol_wt=13044
     Region          6..120
                     /region_name="MazF"
                     /note="mRNA-degrading endonuclease MazF, toxin component
                     of the MazEF toxin-antitoxin module [Defense mechanisms];
                     COG2337"
                     /db_xref="CDD:441908"
ORIGIN      
        1 mvkartphrg eiwyfnpdpv aghelqgphy civvtdkkln nvlkvamccp istganaars
       61 tgvtvnvlpr dtqtgnlhgv vlchqlkavd liargakfht vadeklisev isklvnlidp
      121 q