MFS transporter [Shigella flexneri].

LOCUS       WP_000225683             494 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000225683
VERSION     WP_000225683.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     Protein         1..494
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=52161
     Region          58..488
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(65..66,69..70,73,105,155..156,158..160,163,183,
                     186..187,190,314,317..318,321..323,326,354,358,410..411,
                     415,419,435,438..439,442..443,446)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mvaihllpvs ynsatstvni sariipllii hqrykipmpk vqadglplpq rygailtivi
       61 gismavldga ianvalptia tdlhatpass iwvvnayqia ivisllsfsf lgdmfgyrri
      121 ykcglvvfll sslfcalsds lqmltlarvi qgfggaalms vntalirliy pqrflgrgmg
      181 insfivavss aagptiaaai lsiaswkwlf linvplgiia lllamrflpp ngsraskprf
      241 dlpsavmnal tfgllitals gfaqgqsltl iaaelvvmvv vgiffirrql slpvpllpvd
      301 llriplfsls ictsvcsfca qmlamvslpf ylqtvlgrse vetgllltpw platmvmapl
      361 agyliervha gllgalglfi matglfslvl lpaspadini iwpmilcgag fglfqspnnh
      421 tiitsaprer sggasgmlgt arllgqssga alvalmlnqf gdngthvslm aaailaviaa
      481 cvsglritqp rara