MULTISPECIES: sugar metabolism global transcriptional regulator Mlc

LOCUS       WP_000225276             406 aa            linear   BCT 21-JAN-2024
            [Enterobacteriaceae].
ACCESSION   WP_000225276
VERSION     WP_000225276.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Schiefner,A., Gerber,K., Seitz,S., Welte,W., Diederichs,K. and
            Boos,W.
  TITLE     The crystal structure of Mlc, a global regulator of sugar
            metabolism in Escherichia coli
  JOURNAL   J Biol Chem 280 (32), 29073-29079 (2005)
   PUBMED   15929984
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Tanaka,Y., Itoh,F., Kimata,K. and Aiba,H.
  TITLE     Membrane localization itself but not binding to IICB is directly
            responsible for the inactivation of the global repressor Mlc in
            Escherichia coli
  JOURNAL   Mol Microbiol 53 (3), 941-951 (2004)
   PUBMED   15255904
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Seitz,S., Lee,S.J., Pennetier,C., Boos,W. and Plumbridge,J.
  TITLE     Analysis of the interaction between the global regulator Mlc and
            EIIBGlc of the glucose-specific phosphotransferase system in
            Escherichia coli
  JOURNAL   J Biol Chem 278 (12), 10744-10751 (2003)
   PUBMED   12529317
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Plumbridge,J.
  TITLE     DNA binding sites for the Mlc and NagC proteins: regulation of
            nagE, encoding the N-acetylglucosamine-specific transporter in
            Escherichia coli
  JOURNAL   Nucleic Acids Res 29 (2), 506-514 (2001)
   PUBMED   11139621
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Decker,K., Plumbridge,J. and Boos,W.
  TITLE     Negative transcriptional regulation of a positive regulator: the
            expression of malT, encoding the transcriptional activator of the
            maltose regulon of Escherichia coli, is negatively controlled by
            Mlc
  JOURNAL   Mol Microbiol 27 (2), 381-390 (1998)
   PUBMED   9484893
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR008037
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..406
                     /gene="mlc"
                     /gene_synonym="dgsA"
     Protein         1..406
                     /product="sugar metabolism global transcriptional
                     regulator Mlc"
                     /calculated_mol_wt=44159
     Region          20..60
                     /region_name="HTH_CRP"
                     /note="helix_turn_helix, cAMP Regulatory protein
                     C-terminus; DNA binding domain of prokaryotic regulatory
                     proteins belonging to the catabolite activator protein
                     family; cl46859"
                     /db_xref="CDD:481199"
     Region          84..406
                     /region_name="ASKHA_ATPase_ROK_Mlc"
                     /note="ATPase-like domain of protein Mlc and similar
                     proteins; cd24074"
                     /db_xref="CDD:466924"
ORIGIN      
        1 mvaenqpghi dqikqtnaga vyrlidqlgp vsridlsrla qlapasitki vremleahlv
       61 qeleikeagn rgrpavglvv eteawhylsl risrgeifla lrdlssklvv eesqelalkd
      121 dsplldriis hidqffirhq kklerltsia itlpgiidte ngivhrmpfy edvkemplge
      181 aleqhtgvpv yiqhdisawt maealfgasr gardviqvvi dhnvgagvit dghllhagss
      241 slveightqv dpygkrcycg nhgcletias vdsilelaql rlnqsmssml hgqpltvdsl
      301 cqaalrgdll akdiitgvga hvgrilaimv nlfnpqkili gsplskaadi lfpvisdsir
      361 qqalpaysqh isvestqfsn qgtmagaalv kdamyngsll irllqg