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LOCUS WP_000225096 406 aa linear BCT 17-JUL-2023 [Salmonella]. ACCESSION WP_000225096 VERSION WP_000225096.1 KEYWORDS RefSeq. SOURCE Salmonella ORGANISM Salmonella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae. REFERENCE 1 (residues 1 to 406) AUTHORS Schiefner,A., Gerber,K., Seitz,S., Welte,W., Diederichs,K. and Boos,W. TITLE The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli JOURNAL J Biol Chem 280 (32), 29073-29079 (2005) PUBMED 15929984 REFERENCE 2 (residues 1 to 406) AUTHORS Tanaka,Y., Itoh,F., Kimata,K. and Aiba,H. TITLE Membrane localization itself but not binding to IICB is directly responsible for the inactivation of the global repressor Mlc in Escherichia coli JOURNAL Mol Microbiol 53 (3), 941-951 (2004) PUBMED 15255904 REFERENCE 3 (residues 1 to 406) AUTHORS Seitz,S., Lee,S.J., Pennetier,C., Boos,W. and Plumbridge,J. TITLE Analysis of the interaction between the global regulator Mlc and EIIBGlc of the glucose-specific phosphotransferase system in Escherichia coli JOURNAL J Biol Chem 278 (12), 10744-10751 (2003) PUBMED 12529317 REFERENCE 4 (residues 1 to 406) AUTHORS Plumbridge,J. TITLE DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli JOURNAL Nucleic Acids Res 29 (2), 506-514 (2001) PUBMED 11139621 REFERENCE 5 (residues 1 to 406) AUTHORS Decker,K., Plumbridge,J. and Boos,W. TITLE Negative transcriptional regulation of a positive regulator: the expression of malT, encoding the transcriptional activator of the maltose regulon of Escherichia coli, is negatively controlled by Mlc JOURNAL Mol Microbiol 27 (2), 381-390 (1998) PUBMED 9484893 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: BlastRule Evidence Accession :: NBR008037 Evidence Source :: NCBI ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..406 /organism="Salmonella" /db_xref="taxon:590" gene 1..406 /gene="mlc" /gene_synonym="dgsA" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" Protein 1..406 /product="sugar metabolism global transcriptional regulator Mlc" /calculated_mol_wt=44104 Region 20..60 /region_name="HTH_CRP" /note="helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; cl46859" /db_xref="CDD:481199" Region 84..406 /region_name="ASKHA_ATPase_ROK_Mlc" /note="ATPase-like domain of protein Mlc and similar proteins; cd24074" /db_xref="CDD:466924" ORIGIN 1 mvadsqpghi dqikqtnaga vyrlidqlgp vsridlsrla qlapasitki vremleahlv 61 qeleikeags rgrpavglmv eteawhylsi risrgeifla lrdlssklvv eeclplplte 121 atplleriit hvdrfftrhq qklerltsia itlpgiidte ngvvhrmpyy edvkemplgd 181 slerhtgvpv yiqhdisawt maealfgasr gardviqvvi dhnvgagvit dghllhagss 241 slveightqv dpygkrcycg nhgcletias vdsvleltql rlnqsmssml hgqpltvdsl 301 cqaamqgdll akdiisgvga hvgrilaimv nlfnpqkili gsplskaadi lfpaiadsir 361 qqalpaysrn tvvestqftn qgtmagaalv kdamyngsll irllqg